Department of Biotechnology, University of Engineering & Management, Kolkata, India.
Department of Biotechnology, Maulana Abul Kalam Azad University of Technology, Kolkata, West Bengal, India.
Appl Biochem Biotechnol. 2022 Oct;194(10):4625-4638. doi: 10.1007/s12010-022-04033-0. Epub 2022 Jul 2.
Biofilms are groups of adherent cell communities that cohere to the biotic and abiotic surfaces with the help of extracellular polymeric substances (EPS). EPS allow bacteria to form a biofilm that facilitates their binding to biotic and abiotic surfaces and provides resistance to the host immune responses and to antibiotics. There are efforts that have led to the development of natural compounds that can overcome this biofilm-mediated resistance. Essential oils (EOs) are a unique mixture of compounds that plays a key role in preventing the development of biofilm. The present overview focusses on the role of various types of citrus essential oils in acting against the biofilm, and the antibiofilm properties of natural compounds that may show an avenue to treat the multidrug-resistant bacteria.
生物膜是由附着细胞群落组成的，这些群落借助细胞外多聚物（EPS）黏附在生物和非生物表面上。EPS 使细菌能够形成生物膜，从而促进它们与生物和非生物表面的结合，并对宿主免疫反应和抗生素产生抗性。人们已经做出了一些努力，开发出了可以克服这种生物膜介导的抗性的天然化合物。精油（EOs）是一种独特的化合物混合物，在防止生物膜形成方面起着关键作用。本综述重点介绍了各种类型的柑橘精油在对抗生物膜方面的作用，以及可能为治疗多药耐药菌开辟途径的天然化合物的抗生物膜特性。
