The First Clinical Medical College of Zhejiang Chinese Medical University, No 548, Binwen Road, Hangzhou, 310051, Zhejiang Province, China.
The Second Clinical Medical College of Zhejiang Chinese Medical University, No 548, Binwen Road, Hangzhou, 310051, Zhejiang Province, China.
Lipids Health Dis. 2022 Jul 2;21(1):57. doi: 10.1186/s12944-022-01658-2.
The incidence rate of metabolic-associated fatty liver disease (MAFLD) is increasing annually; however, there are still no effective methods for establishing an early diagnosis and conducting real-time tracing. Vaspin can affect the metabolic processes in the body, and it is closely associated with many metabolic diseases. Many previous studies have speculated on the association between vaspin and MAFLD, but the results of these studies have not been conclusive. This meta-analysis examined the differences in circulating vaspin levels between patients with MAFLD and healthy individuals.
Six databases and other sources were searched with free terms and Medical Subject Headings terms, and a total of 13 articles were included (900 cases and 669 controls). RevMan 5.3 and Stata 16 were used for analysis. The standardised mean difference (SMD) and 95% confidence interval (CI) were used to assess the overall outcomes. Cohen's kappa coefficient was applied to examine the differences between the two authors in the selection of studies and in the evaluation of the quality of evidence for the studies.
The results demonstrated that there was no significant difference in the circulating vaspin levels between the MAFLD group and healthy group (SMD = 0.46, 95% CI: [- 0.12, 1.04]). The subgroup analysis suggested that area and body mass index (BMI) may be the sources of heterogeneity, and the results of univariate meta-regression analysis were consistent with those of the subgroup analysis (P = 0.005 and P < 0.001, respectively). Furthermore, BMI may better explain the source of heterogeneity (P = 0.032) in the multivariate meta-regression analysis.
In summary, no significant correlation was observed between the circulating vaspin levels and MAFLD. BMI may be an important factor affecting this correlation, which may provide a reference for further studies on mechanism and diagnosis of MAFLD.
代谢相关脂肪性肝病（MAFLD）的发病率逐年上升，但目前仍缺乏有效的早期诊断和实时追踪方法。内脏脂肪素（vaspin）可影响机体的代谢过程，与多种代谢性疾病密切相关。许多既往研究推测了内脏脂肪素与 MAFLD 之间的相关性，但这些研究的结果并不一致。本荟萃分析旨在探讨 MAFLD 患者与健康人群循环内脏脂肪素水平的差异。
通过自由词和医学主题词检索了 6 个数据库和其他来源，共纳入 13 项研究（900 例患者和 669 例对照）。采用 RevMan 5.3 和 Stata 16 进行分析。采用标准化均数差（SMD）及其 95%置信区间（CI）评估汇总结果。应用 Cohen's kappa 系数评估两位作者在研究选择和证据质量评估方面的差异。
结果显示，MAFLD 组与健康组的循环内脏脂肪素水平无显著差异（SMD=0.46，95%CI：-0.12，1.04）。亚组分析提示，研究地区和体质量指数（BMI）可能是异质性的来源，单变量meta 回归分析结果与亚组分析结果一致（P=0.005 和 P<0.001）。进一步的多变量meta 回归分析表明，BMI 可能更好地解释了异质性的来源（P=0.032）。
综上所述，循环内脏脂肪素水平与 MAFLD 之间无显著相关性。BMI 可能是影响这一相关性的重要因素，这可能为 MAFLD 机制和诊断的进一步研究提供参考。
