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纳米医学研究中的多细胞肿瘤球体：一种视角。

Multicellular Tumor Spheroids in Nanomedicine Research: A Perspective.

作者信息

Rossi Martina, Blasi Paolo

机构信息

Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.

出版信息

Front Med Technol. 2022 Jun 15;4:909943. doi: 10.3389/fmedt.2022.909943. eCollection 2022.

DOI:10.3389/fmedt.2022.909943
PMID:35782575
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9240201/
Abstract

Multicellular tumor spheroids are largely exploited in cancer research since they are more predictive than bi-dimensional cell cultures. Nanomedicine would benefit from the integration of this three-dimensional model in screening protocols. In this brief work, we discuss some of the issues that cancer nanomedicine will need to consider in the switch from bi-dimensional to three-dimensional multicellular tumor spheroid models.

摘要

多细胞肿瘤球体在癌症研究中得到了广泛应用，因为它们比二维细胞培养更具预测性。纳米医学将受益于将这种三维模型整合到筛选方案中。在这项简短的工作中，我们讨论了癌症纳米医学在从二维向三维多细胞肿瘤球体模型转变过程中需要考虑的一些问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/473f/9240201/7826aabe4c18/fmedt-04-909943-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/473f/9240201/bdc52fa31c2a/fmedt-04-909943-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/473f/9240201/7826aabe4c18/fmedt-04-909943-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/473f/9240201/bdc52fa31c2a/fmedt-04-909943-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/473f/9240201/7826aabe4c18/fmedt-04-909943-g0002.jpg

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