Zhang Guoshun, Shang Hua, Liu Bin, Wu Guikai, Wu Diyang, Wang Liuqing, Li Shengnan, Wang Zhiyuan, Wang Suying, Yuan Juxiang
School of Public Health, North China University of Science and Technology, Tangshan, China.
Department of Gastroenterology, Affiliated Hospital of North China University of Technology, Tangshan, China.
Front Genet. 2022 Jun 16;13:661348. doi: 10.3389/fgene.2022.661348. eCollection 2022.
Colorectal cancer is one of the most common malignant tumors in the digestive system. Traditional diagnosis and treatment methods have not significantly improved the overall survival of patients. In this study, we explored the value of as a biomarker in predicting the prognosis of colorectal cancer patients. We used the TCGA database to reveal the relationship between mRNA level and prognosis, methylation, and immune invasion in colorectal cancer. The results showed that the expression of was increased in colorectal cancer. The overall survival of patients with high expression of was significantly lower than patients with low expression of . Cox regression analysis showed that high expression of was an independent risk factor for poor prognosis in colorectal cancer patients. In addition, we used three datasets to perform a meta-analysis, which further confirmed the reliability of the results. Furthermore, we revealed that could significantly inhibit the proliferation of colorectal cancer cells by inhibiting the autophagy process and was associated with several immune cells, especially CD8 + T cells. Finally, four small molecule drugs with potential inhibition of expression were found by CMap analysis. This study demonstrates for the first time that is a potential pathogenic factor, which may play a significant role in colorectal cancer.
结直肠癌是消化系统最常见的恶性肿瘤之一。传统的诊断和治疗方法并未显著提高患者的总体生存率。在本研究中，我们探讨了[未提及具体指标]作为生物标志物在预测结直肠癌患者预后方面的价值。我们使用TCGA数据库揭示[未提及具体指标]mRNA水平与结直肠癌预后、甲基化及免疫浸润之间的关系。结果显示，[未提及具体指标]在结直肠癌中表达升高。[未提及具体指标]高表达患者的总体生存率显著低于低表达患者。Cox回归分析表明，[未提及具体指标]高表达是结直肠癌患者预后不良的独立危险因素。此外，我们使用三个数据集进行荟萃分析，进一步证实了结果的可靠性。此外，我们发现[未提及具体指标]可通过抑制自噬过程显著抑制结直肠癌细胞的增殖，并与多种免疫细胞相关，尤其是CD8 + T细胞。最后，通过CMap分析发现了四种具有潜在抑制[未提及具体指标]表达作用的小分子药物。本研究首次证明[未提及具体指标]是一种潜在的致病因素，可能在结直肠癌中发挥重要作用。
