Higashisaka Kazuma, Nagano Kazuya, Yoshioka Yasuo, Tsutsumi Yasuo
Graduate School of Pharmaceutical Sciences, Osaka University.
Biol Pharm Bull. 2017;40(3):243-248. doi: 10.1248/bpb.b16-00854.
In the past decade, nanotechnology has advanced rapidly, and many products containing nanoparticles are now an important part of our daily lives. Despite our increasing exposure to nanoparticles, however, information regarding the absorption, distribution, metabolism, excretion, and toxicity of nanoparticles remains limited. In this review, we introduce our group's ongoing research into the biological effects and toxicities of nanoparticles, which we broadly refer to as "nano-safety research." In addition to determining the biological effects of nanoparticles and elucidating the underlying mechanisms of those effects, we are also exploring the associations among the physicochemical properties and kinetics of nanoparticles. Furthermore, we are currently developing a battery of biomarkers that we hope will be used to predict the biological effects of nanoparticles during the early stages of development. Our research provides valuable basic information on the safety of nanoparticles. We hope that this information will be used for the development of better assessments of nanoparticles safety and for the creation of more appropriate regulations to ensure not only the safety but also the sustainability of nanotechnology.
在过去十年中，纳米技术发展迅速，现在许多含有纳米颗粒的产品已成为我们日常生活的重要组成部分。然而，尽管我们越来越多地接触纳米颗粒，但有关纳米颗粒的吸收、分布、代谢、排泄和毒性的信息仍然有限。在这篇综述中，我们介绍了我们团队正在进行的关于纳米颗粒生物效应和毒性的研究，我们将其统称为“纳米安全研究”。除了确定纳米颗粒的生物效应并阐明这些效应的潜在机制外，我们还在探索纳米颗粒的物理化学性质和动力学之间的关联。此外，我们目前正在开发一系列生物标志物，希望这些生物标志物能够在纳米颗粒开发的早期阶段用于预测其生物效应。我们的研究为纳米颗粒的安全性提供了有价值的基础信息。我们希望这些信息将用于更好地评估纳米颗粒的安全性，并制定更合适的法规，以确保纳米技术不仅安全，而且可持续发展。
