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来自一家三级护理中心的患者中 D-二聚体水平与 SARS-CoV-2 急性后期后遗症之间的关联。

Association between D-dimer levels and post-acute sequelae of SARS-CoV-2 in patients from a tertiary care center.

机构信息

Research Center for Cellular Genomics & Cancer Research, Sree Balaji Medical College & Hospital, Chennai, Tamilnadu, 600044, India.

Department of Biochemistry, Sree Balaji Medical College & Hospital, Chennai, Tamilnadu, 600044, India.

出版信息

Biomark Med. 2022 Aug;16(11):833-838. doi: 10.2217/bmm-2022-0050. Epub 2022 Jul 5.

Abstract

Post-acute sequelae of SARS-CoV-2 (PASC) is becoming an important concern in SARS-CoV-infected people. The pathophysiology behind PASC is unknown, and much study should be carried out to check the D-dimer levels in the PASC population. In COVID-19 patients, the D-dimer level was checked during admission and discharge, and a follow-up study was carried out after 3 and 6 months of discharge. The results were compared with the appropriate statistical tests. Patients had a high D-dimer value than the normal range, and the elevated D-dimer value continued to increase up to 6 months. Persistence of PASC has a direct correlation with increased D-dimer values. D-dimer can be used as biomarker in PASC patients.

摘要

SARS-CoV-2 的急性后期后遗症(PASC)正在成为 SARS-CoV 感染者关注的一个重要问题。PASC 背后的病理生理学尚不清楚,应该进行大量研究以检查 PASC 人群中的 D-二聚体水平。在 COVID-19 患者中,在入院和出院时检查了 D-二聚体水平,并在出院后 3 个月和 6 个月进行了随访研究。将结果与适当的统计检验进行了比较。患者的 D-二聚体值高于正常值,并且升高的 D-二聚体值持续增加至 6 个月。PASC 的持续存在与 D-二聚体值的升高直接相关。D-二聚体可用作 PASC 患者的生物标志物。

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