C R Biol. 2021 Dec 20;344(4):357-371. doi: 10.5802/crbiol.70.
Most bacterial ribonucleases (RNases) known to date have been identified in either Escherichia coli or Bacillus subtilis. These two organisms lie on opposite poles of the phylogenetic spectrum, separated by 1-3 billion years of evolution. As a result, the RNA maturation and degradation machineries of these two organisms have little overlap, with each having a distinct set of RNases in addition to a core set of enzymes that is highly conserved across the bacterial spectrum. In this paper, we describe what the functions performed by major RNases in these two bacteria, and how the evolutionary space between them can be described by two opposing gradients of enzymes that fade out and fade in, respectively, as one walks across the phylogenetic tree from E. coli to B. subtilis.
迄今为止，已知的大多数细菌核糖核酸酶（RNase）都在大肠杆菌或枯草芽孢杆菌中被发现。这两种生物体处于进化谱系的两个极端，彼此相隔 10 亿至 30 亿年的进化时间。因此，这两种生物体的 RNA 成熟和降解机制几乎没有重叠，除了一组在细菌谱中高度保守的核心酶外，每种生物体都有一组独特的 RNase。在本文中，我们描述了这两种细菌中主要 RNase 所执行的功能，以及如何通过两种相反的酶梯度来描述它们之间的进化空间，当沿着从大肠杆菌到枯草芽孢杆菌的进化树行走时，这两种酶梯度分别逐渐消失和出现。
