Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA.
Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA.
Cell Rep. 2022 Jul 5;40(1):111042. doi: 10.1016/j.celrep.2022.111042.
Cholinergic interneurons (ChIs) in the nucleus accumbens (NAc) play a central role in motivated behaviors and associated disorders. However, while the activation of ChIs has been well studied in the dorsal striatum, little is known about how they are engaged in the NAc. Here, we find that the ventral hippocampus (vHPC) and the paraventricular nucleus of the thalamus (PVT) are the main excitatory inputs to ChIs in the NAc medial shell. While the PVT activates ChIs, the vHPC evokes a pronounced pause in firing through prominent feedforward inhibition. In contrast to the dorsal striatum, this inhibition reflects strong connections onto ChIs from local parvalbumin interneurons. Our results reveal the mechanisms by which different long-range inputs engage ChIs, highlighting fundamental differences in local connectivity across the striatum.
伏隔核（NAc）中的胆碱能中间神经元（ChIs）在动机行为及其相关疾病中发挥着核心作用。然而，虽然背侧纹状体中 ChIs 的激活已得到充分研究，但对于它们在 NAc 中的参与方式知之甚少。在这里，我们发现腹侧海马（vHPC）和丘脑室旁核（PVT）是 NAc 内侧壳中 ChIs 的主要兴奋性输入。虽然 PVT 会激活 ChIs，但 vHPC 通过明显的前馈抑制引起明显的发射暂停。与背侧纹状体相反，这种抑制反映了来自局部 PV 中间神经元的强烈连接到 ChIs 上。我们的研究结果揭示了不同长程输入激活 ChIs 的机制，突出了纹状体中局部连接的根本差异。
