Bisetegn Habtye, Feleke Daniel Getacher, Ebrahim Hussen, Tesfaye Melkam, Gedefie Alemu, Erkihun Yonas
College of Medicine and Health Sciences, Department of Medical Laboratory Sciences, Wollo University, Dessie, Ethiopia.
Department of Microbiology, Immunology and Parasitology, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Interdiscip Perspect Infect Dis. 2022 Jun 27;2022:5954536. doi: 10.1155/2022/5954536. eCollection 2022.
is an intravascular parasite that interacts with all components of the host blood. Nearly, 10% of S. mansoni-infected patients progress to severe hepatosplenic Schistosomiasis is characterized by periportal fibrosis, obstruction of intrahepatic veins, presinusoidal portal hypertension, and splenomegaly. Thus, this study aimed to compare the basic coagulation profiles and platelet parameters of infected adults and noninfected individuals as controls at Haik Primary Hospital, Northeast Ethiopia.
A comparative cross-sectional study was conducted at Haik Primary Hospital from April to June 2021. The diagnosis and intensity of infection was determined using the Kato-Katz technique. The coagulation profiles and platelet parameters were analyzed using coagulation and hematology analyzers. Data were analyzed using SPSS version 26.0. The Kolmogorov-Smirnov and Shapiro-Wilk tests were done to check the distribution of continuous variables. The Mann-Whitney test was used to compare the coagulation profiles and platelet parameters. Spearman's rank-order correlation was done to assess the correlation between the intensity of infection and coagulation profiles and platelet parameters. In all comparison, a value <0.05 was considered statistically significant.
In this study, a total of 180 study participants (90 -infected adults and 90 controls) were included. Of the total -infected adults, 55.6%, 28.9%, 33, and 15.6% had light, moderate, and heavy intensity of infections, respectively. All -infected study participants had prolonged prothrombin time (PT) and international normalized ratio (INR). Moreover, about 80% of -infected adults had prolonged activated partial thromboplastin time (APTT). Thrombocytopenia was found in 26.7% of the -infected adults. The Mann-Whitney test showed a statistically significant difference in coagulation profiles between -infected adults and healthy controls (-value ≤0.001). The Kruskal-Wallis H-test showed a significant difference in PT, APTT, and INR between the intensity of infection and healthy controls (-value <0.05).
This study showed a prolonged coagulation time in -infected individuals. Thus, screening of schistosomiasis patients for hemostatic abnormalities and treating the underlying disorder is crucial.
是一种血管内寄生虫，可与宿主血液的所有成分相互作用。近10%的曼氏血吸虫感染患者会发展为严重的肝脾血吸虫病，其特征为门周纤维化、肝内静脉阻塞、窦前门静脉高压和脾肿大。因此，本研究旨在比较埃塞俄比亚东北部海克初级医院感染血吸虫的成年人与作为对照的未感染个体的基本凝血指标和血小板参数。
2021年4月至6月在海克初级医院进行了一项比较性横断面研究。使用加藤厚涂片法确定感染的诊断和强度。使用凝血分析仪和血液学分析仪分析凝血指标和血小板参数。使用SPSS 26.0版软件进行数据分析。进行柯尔莫哥洛夫-斯米尔诺夫检验和夏皮罗-威尔克检验以检查连续变量的分布。使用曼-惠特尼检验比较凝血指标和血小板参数。进行斯皮尔曼等级相关分析以评估感染强度与凝血指标和血小板参数之间的相关性。在所有比较中，P值<0.05被认为具有统计学意义。
本研究共纳入180名研究参与者（90名感染血吸虫的成年人和90名对照）。在所有感染血吸虫的成年人中，分别有55.6%、28.9%、33%和15.6%的人感染程度为轻度、中度和重度。所有感染血吸虫的研究参与者的凝血酶原时间（PT）和国际标准化比值（INR）均延长。此外，约80%感染血吸虫的成年人活化部分凝血活酶时间（APTT）延长。26.7%感染血吸虫的成年人出现血小板减少。曼-惠特尼检验显示，感染血吸虫的成年人与健康对照之间的凝血指标存在统计学显著差异（P值≤0.001）。克鲁斯卡尔-沃利斯H检验显示，感染强度与健康对照之间的PT、APTT和INR存在显著差异（P值<0.05）。
本研究显示感染血吸虫的个体凝血时间延长。因此，对血吸虫病患者进行止血异常筛查并治疗潜在疾病至关重要。
