Abebe Wagaw, Asmare Zelalem, Barasa Silesh, Woldesenbet Dagmawi, Lemma Wossenseged, Derso Adane
Department of Medical Laboratory Sciences, College of Health Sciences, Woldia University, Woldia, Ethiopia.
Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Arba Minch University, Arba Minch, Ethiopia.
J Parasit Dis. 2024 Jun;48(2):308-319. doi: 10.1007/s12639-024-01669-z. Epub 2024 May 11.
Malaria and schistosomiasis are infectious diseases that cause hematological profiles abnormalities. Malaria and co-infection causes exacerbation of health consequences and co-morbidities. The aim of this study was to assess the selected hematological profiles among malaria and co-infected patients at Dembiya Selected Health Institutions. An institutional-based comparative cross-sectional study was conducted from March 30 to August 10, 2022. A total of 140 individuals were enrolled in the study using a convenient sampling technique. Wet mount and Kato Katz technique were conducted to detect in Stool sample. Blood films were prepared for the detection of . The data was coded and entered into EpiData version 3.1 before being analyzed with SPSS version 25. A -value of less than 0.05 was considered statistically significant. Mean of WBC, neutrophil, lymphocyte, eosinophil, RBC, hemoglobin, and hematocrit [4.IU/L,2.2 IU/L, 1.4 IU/L, 0.1 IU/L, 3.13 IU/L, 9.5 g/dL, and 28.7%, resepectively] in co-infected were significantly lower than [7.5 IU/L, 4.6 IU/L, 2.1 IU/L, 0.38 IU/L, 4.8 IU/L, 14.6 g/dL, and 43.7%, resepectively] in the healthy control participants. Mean of RBC, hemoglobin, and hematocrit [3.13 IU/L, 9.5 g/dL, 28.7%, resepectively] in co-infected were significantly lower compared to [3.8 IU/L, 11.5 g/dL, 33.9%, resepectively] in the malaria monoinfected participants and [3.7 IU/L,11.5 g/dL, 33.6%, resepectively] in the monoinfected participants. The result of hematological profiles in healthy participants had no significant difference compared to light,moderate and heavy infection intensity in coinfection. The number of eggs per gram of stool had been negatively correlated with hematological profiles of co-infected participants except lymphocyte and monocyte which correlated positively. Hematological profiles status in coinfection were significantly altered compared to malaria monoinfection, monoinfection, and healthy participants.Therefore, hematological tests should be used to monitor and manage coinfection related complications, and to reduce coinfection associated morbidity and mortality.
疟疾和血吸虫病是导致血液学指标异常的传染病。疟疾与其他感染共同导致健康后果和合并症的加剧。本研究的目的是评估登比耶选定医疗机构中疟疾及合并感染患者的选定血液学指标。2022年3月30日至8月10日进行了一项基于机构的比较横断面研究。采用方便抽样技术，共有140人纳入研究。对粪便样本采用湿片法和加藤厚涂片法进行检测。制备血涂片用于检测[此处原文缺失检测对象]。数据编码后录入EpiData 3.1版本，然后用SPSS 25版本进行分析。P值小于0.05被认为具有统计学意义。合并感染患者的白细胞、中性粒细胞、淋巴细胞、嗜酸性粒细胞、红细胞、血红蛋白和血细胞比容的平均值[分别为4.1IU/L、2.2IU/L、1.4IU/L、0.1IU/L、3.13IU/L、9.5g/dL和28.7%]显著低于健康对照参与者[分别为7.5IU/L、4.6IU/L、2.1IU/L、0.38IU/L、4.8IU/L、14.6g/dL和43.7%]。合并感染患者的红细胞、血红蛋白和血细胞比容平均值[分别为3.13IU/L、9.5g/dL、28.7%]显著低于疟疾单一感染参与者[分别为3.8IU/L、11.5g/dL、33.9%]和[此处原文缺失单一感染对象]单一感染参与者[分别为3.7IU/L、11.5g/dL、33.6%]。健康参与者的血液学指标结果与合并感染中轻度、中度和重度[此处原文缺失感染对象]感染强度相比无显著差异。每克粪便中的[此处原文缺失虫卵对象]虫卵数量与合并感染参与者的血液学指标呈负相关，但淋巴细胞和单核细胞呈正相关。与疟疾单一感染、[此处原文缺失单一感染对象]单一感染和健康参与者相比，合并感染中的血液学指标状态有显著改变。因此，血液学检测应用于监测和管理合并感染相关并发症，并降低合并感染相关的发病率和死亡率。
