Abebe Wagaw, Lemma Wossenseged, Tegegne Yalewayker, Sisay Assefa, Misganaw Tadesse, Ayana Sisay, Kasew Desie, Debash Marye Nigatie, Zemariam Alemu Birara, Emagneneh Tadele, Derso Adane
Department of Medical Laboratory Sciences, College of Health Sciences, Woldia University, Woldia, Ethiopia.
Department of Medical Parasitology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
BMC Microbiol. 2025 Mar 5;25(1):119. doi: 10.1186/s12866-025-03838-3.
Schistosomiasis is a parasitic disease that causes coagulation disorders and biochemical abnormalities. This is due to liver failure, platelet destruction, disruption of blood flow, and endothelial function by the schistosomes. However, there is no adequate data on biochemical and coagulation profiles and platelet count of patients infected with Schistosoma mansoni in Dembiya Selected Health Institutions. Hence, the aim of this study was to assess the effect of Schistosoma mansoni infection on selected biochemical and coagulation profiles and platelet count.
An institutional-based comparative cross-sectional study was conducted from March to August 2022 at Dembiya Primary Hospital, Chuahit Health Center, and Abrija Health Center, Northwest Ethiopia. A total of 70 individuals were enrolled in the study using convenient sampling techniques. A stool sample was collected for Schistosoma mansoni detection. Likewise, a blood sample was collected for biochemical and coagulation profiles and platelet count analysis. The data were analyzed using SPSS version 25. A p-value less than 0.05 was considered statistically significant.
Median values for alanine aminotransferase, aspartate aminotransferase, creatinine, total bilirubin, and direct bilirubin values were significantly higher, while total protein and glucose were significantly lower in Schistosoma mansoni infected than in the healthy control participants (P < 0.05). Prothrombin time, activated partial thromboplastin time, and international normalization ratio were significantly higher, while the platelet count was significantly lower in the Schistosoma mansoni infected than healthy control participants (P < 0.05). The values of alanine aminotransferase, aspartate aminotransferase, creatinine, total bilirubin, direct bilirubin, prothrombin time, activated partial thromboplastin time, and international normalization ratio were significantly higher, while total protein, glucose, and platelet count were significantly lower in those with moderate and heavy Schistosoma mansoni infection intensity compared to healthy control participants (P < 0.05). The number of Schistosoma mansoni eggs per gram of stool had a positive correlation with biochemical and coagulation profiles, except for total protein, glucose, and platelet count, which were correlated negatively in Schistosoma mansoni infected participants (P < 0.05).
Biochemical and coagulation profiles, including alanine aminotransferase, aspartate aminotransferase, creatinine, total bilirubin, direct bilirubin, glucose, total protein, prothrombin time, activated partial thromboplastin time, international normalization ratio, and platelet count, were significantly altered in S. mansoni infected participants compared to controls (p < 0.05). These findings underscore the need for routine biochemical and coagulation monitoring in endemic areas.
血吸虫病是一种导致凝血功能障碍和生化异常的寄生虫病。这是由于血吸虫导致肝功能衰竭、血小板破坏、血流中断和内皮功能受损。然而，在登比耶选定的医疗机构中，关于曼氏血吸虫感染患者的生化和凝血指标以及血小板计数，尚无充分数据。因此，本研究的目的是评估曼氏血吸虫感染对选定的生化和凝血指标以及血小板计数的影响。
2022年3月至8月，在埃塞俄比亚西北部的登比耶初级医院、楚阿希特健康中心和阿布里亚健康中心进行了一项基于机构的比较横断面研究。采用方便抽样技术，共纳入70名个体参与研究。采集粪便样本用于检测曼氏血吸虫。同样，采集血液样本用于生化和凝血指标分析以及血小板计数。数据使用SPSS 25版进行分析。p值小于0.05被认为具有统计学意义。
曼氏血吸虫感染患者的丙氨酸氨基转移酶、天冬氨酸氨基转移酶、肌酐、总胆红素和直接胆红素的中位数显著高于健康对照参与者，而总蛋白和葡萄糖则显著低于健康对照参与者（P < 0.05）。曼氏血吸虫感染患者的凝血酶原时间、活化部分凝血活酶时间和国际标准化比值显著高于健康对照参与者，而血小板计数则显著低于健康对照参与者（P < 0.05）。与健康对照参与者相比，中度和重度曼氏血吸虫感染强度患者的丙氨酸氨基转移酶、天冬氨酸氨基转移酶、肌酐、总胆红素、直接胆红素、凝血酶原时间、活化部分凝血活酶时间和国际标准化比值显著更高，而总蛋白、葡萄糖和血小板计数则显著更低（P < 0.05）。每克粪便中的曼氏血吸虫卵数量与生化和凝血指标呈正相关，但在曼氏血吸虫感染参与者中，总蛋白、葡萄糖和血小板计数呈负相关（P < 0.05）。
与对照组相比，曼氏血吸虫感染参与者的生化和凝血指标，包括丙氨酸氨基转移酶、天冬氨酸氨基转移酶、肌酐、总胆红素、直接胆红素、葡萄糖、总蛋白、凝血酶原时间、活化部分凝血活酶时间、国际标准化比值和血小板计数，均有显著改变（p < 0.05）。这些发现强调了在流行地区进行常规生化和凝血监测的必要性。
