Abebe Wagaw, Lemma Wossenseged, Tegegne Yalewayker, Mekuanint Amare, Yenesew Abebe, Derso Adane
Department of Medical Laboratory Sciences, College of Health Sciences, Woldia University, Woldia, Ethiopia.
Department of Medical Parasitology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
J Trop Med. 2024 Mar 21;2024:9992233. doi: 10.1155/2024/9992233. eCollection 2024.
Malaria and schistosomiasis are infectious diseases that cause biochemical abnormalities. Malaria and coinfection causes exacerbations of health consequences and comorbidities. The study area is found in Ethiopia, where coinfection of malaria and is common. However, there is limited data on the biochemical profiles of patients coinfected with malaria and schistosomiasis in the study area. Hence, this study aimed to assess the effect of malaria and schistosomiasis coinfection on selected biochemical profiles.
An institutional-based comparative cross-sectional study was conducted from March 30 to August 10, 2022. Using a convenient sampling technique, 70 participants (35 cases and 35 controls) were enrolled in the study. was detected in stool samples using the wet mount and the Kato Katz method. To detect , both thick and thin blood films were prepared and stained with Giemsa. The blood sample was processed for the analysis of biochemical profiles. All data were analyzed using SPSS version 25. A value of less than 0.05 was considered statistically significant.
The mean values of alanine aminotransferase and aspartate aminotransferase (37.1 U/L and 41.9 U/L, respectively) in coinfected participants were significantly higher than in the healthy control participants (17.4 U/L and 22.0 U/L, respectively) ( < 0.05). Also, the median values of creatinine, total bilirubin, and direct bilirubin (1.51 mg/dL, 2.35 mg/dL, and 0.91 mg/dL, respectively) in coinfected participants were significantly higher than in the healthy control participants (0.85 mg/dL, 0.42 mg/dL, and 0.12 mg/dL, respectively) ( < 0.05). However, median values of total protein (4.82 g/dL) and mean values of glucose (66.6 mg/dL) in coinfected participants were significantly lower than in the healthy control participants (total protein (7.64 g/dL) and glucose (91.9 mg/dL)) ( < 0.05). The results of biochemical profiles in healthy participants were significantly different from those with light, moderate, and heavy infection intensity in malaria and coinfection ( < 0.05). infection intensity had a positive correlation with biochemical profiles except for total protein and glucose, which correlated negatively in coinfected participants ( > 0.05).
Biochemical profiles in coinfection were significantly changed as compared to healthy individuals. As a result, biochemical profile tests should be utilized to monitor and manage coinfection-related problems, as well as to reduce coinfection-related morbidity and death.
疟疾和血吸虫病是会导致生化异常的传染病。疟疾与其他疾病的合并感染会加剧健康后果和合并症。研究区域位于埃塞俄比亚，疟疾与其他疾病的合并感染很常见。然而，关于该研究区域疟疾和血吸虫病合并感染患者的生化指标数据有限。因此，本研究旨在评估疟疾和血吸虫病合并感染对选定生化指标的影响。
于2022年3月30日至8月10日进行了一项基于机构的比较横断面研究。采用方便抽样技术，招募了70名参与者（35例病例和35名对照）。使用湿片法和加藤厚涂片法在粪便样本中检测（此处原文缺失具体检测内容）。为检测（此处原文缺失具体检测内容），制备了厚血膜和薄血膜并用吉姆萨染色。对血样进行处理以分析生化指标。所有数据均使用SPSS 25版进行分析。P值小于0.05被认为具有统计学意义。
合并感染参与者的丙氨酸氨基转移酶和天冬氨酸氨基转移酶的平均值（分别为37.1 U/L和41.9 U/L）显著高于健康对照参与者（分别为17.4 U/L和22.0 U/L）（P<0.05）。此外，合并感染参与者的肌酐、总胆红素和直接胆红素的中位数（分别为1.51 mg/dL、2.35 mg/dL和0.91 mg/dL）显著高于健康对照参与者（分别为0.85 mg/dL、0.42 mg/dL和0.12 mg/dL）（P<0.05）。然而，合并感染参与者的总蛋白中位数（4.82 g/dL）和葡萄糖平均值（66.6 mg/dL）显著低于健康对照参与者（总蛋白（7.64 g/dL）和葡萄糖（91.9 mg/dL））（P<0.05）。健康参与者的生化指标结果与疟疾和（此处原文缺失具体疾病）合并感染中轻度、中度和重度（此处原文缺失具体感染指标）感染强度的参与者的结果存在显著差异（P<0.05）。除总蛋白和葡萄糖外，（此处原文缺失具体感染指标）感染强度与生化指标呈正相关，在合并感染参与者中总蛋白和葡萄糖呈负相关（P>0.05）。
与健康个体相比，合并感染中的生化指标发生了显著变化。因此，应利用生化指标检测来监测和管理合并感染相关问题，以及降低合并感染相关的发病率和死亡率。
