Song Hyun-Kyung, Park Sun Haeng, Kim Hye Jin, Jang Seol, Kim Taesoo
Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, South Korea.
College of Pharmacy, Seoul National University, Seoul, South Korea.
Front Pharmacol. 2022 Jun 20;13:919230. doi: 10.3389/fphar.2022.919230. eCollection 2022.
Dunn, a traditional Chinese herbal medicine, has various pharmacological activities, such as anti-inflammatory properties. However, to the best of our knowledge, its therapeutic effect on atopic dermatitis (AD) has not been investigated. In this study, we explored the effect of Dunn water extract (SSWex) on AD and . In extract (DfE)-treated NC/Nga mice, the oral administration of SSWex alleviated AD-like symptoms, such as ear thickness, dermatitis score, epidermal thickness, immune cell infiltration, and levels of AD-related serum parameters (immunoglobulin E, histamine, and proinflammatory chemokines). In HaCaT cells, the production of proinflammatory chemokines induced by interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) was inhibited by SSWex pretreatment. SSWex treatment inhibited the phosphorylation of mitogen-activated protein kinase and activation and translocation of transcriptional factors, such as signal transducer and activator of transcription 1 and nuclear factor kappa B in IFN-γ/TNF-α-stimulated HaCaT cells. These results indicate that SSWex may be developed as an efficient therapeutic agent for AD.
独活是一种传统中药，具有多种药理活性，如抗炎特性。然而，据我们所知，其对特应性皮炎（AD）的治疗效果尚未得到研究。在本研究中，我们探讨了独活水提取物（SSWex）对AD的影响。在二氯甲烷提取物（DfE）处理的NC/Nga小鼠中，口服SSWex可减轻AD样症状，如耳厚度、皮炎评分、表皮厚度、免疫细胞浸润以及AD相关血清参数（免疫球蛋白E、组胺和促炎趋化因子）水平。在HaCaT细胞中，SSWex预处理可抑制干扰素-γ（IFN-γ）和肿瘤坏死因子-α（TNF-α）诱导的促炎趋化因子的产生。在IFN-γ/TNF-α刺激的HaCaT细胞中，SSWex处理可抑制丝裂原活化蛋白激酶的磷酸化以及转录因子（如信号转导子和转录激活子1以及核因子κB）的激活和转位。这些结果表明，SSWex可能被开发成为一种治疗AD的有效药物。
