Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Aging Clinical Research, Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Geroscience. 2022 Dec;44(6):2611-2622. doi: 10.1007/s11357-022-00613-4. Epub 2022 Jul 7.
Measuring intrinsic, biological age is a central question in medicine, which scientists have been trying to answer for decades. Age manifests itself differently in different individuals, and chronological age often does not reflect such heterogeneity of health and function. We discuss here the value of measuring age and aging using the comprehensive geriatric assessment (CGA), cornerstone of geriatric medicine, and operationalized assessment tools for prognosis. Specifically, we review the benefits of employing the multidimensional prognostic index (MPI), which collects information about eight domains relevant for the global assessment of the older person (functional and cognitive status, nutrition, mobility and risk of pressure sores, multi-morbidity, polypharmacy, and co-habitation), in the evaluation of the functional status, and in the prediction of health outcomes for older adults. Further integration of biological markers of aging into multidimensional prognostic tools is warranted, as well as actions which could facilitate prognostic assessments for older persons in all healthcare settings.
衡量内在的、生物学年龄是医学中的一个核心问题，几十年来，科学家们一直在试图回答这个问题。年龄在不同个体中的表现不同，而年龄往往不能反映健康和功能的这种异质性。我们在这里讨论使用综合老年评估（CGA）来衡量年龄和衰老的价值，CGA 是老年医学的基石，以及用于预后的操作性评估工具。具体来说，我们回顾了使用多维预后指数（MPI）的好处，MPI 收集了与老年人全面评估相关的八个领域的信息（功能和认知状态、营养、移动性和压疮风险、多种疾病、多药治疗和共同居住），用于评估功能状态，并预测老年人的健康结果。有必要将衰老的生物标志物进一步整合到多维预后工具中，以及在所有医疗保健环境中为老年人进行预后评估提供便利的措施。
