Laboratory of Clinical Pathology and Blood Bank, Mahar Mardjono National Brain Center Hospital, East Jakarta, Indonesia.
Department of Clinical Pathology, Faculty of Medicine University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
J Infect Dev Ctries. 2022 Jun 30;16(6):1096-1100. doi: 10.3855/jidc.15200.
The oligoclonal band indicates presence of antibodies specific to the disease, possibly due to the activation of certain clones of B lymphocytes. This intrathecal immunoglobin synthesis can be persistent for months to years, for example, in respons to paramyxoviruses, herpes virus, coxsackievirus, and Treponema pallidum; or can be synthesized for life, for example in multiple sclerosis and subacute sclerosing panencephalitis (SSPE). We report a case of SSPE in a 15-year-old male patient. The patient had myoclonic jerks that occurred in the thoracal femoral region. Necessary laboratory tests identified reactive anti-measles IgG, which indicates a previous measles infection or exposure to vaccination. This report describes the usefulness of the oligoclonal bands in the diagnosis of the neurodegenerative disease SSPE that is progressive and fatal to the central nervous system due to persistent measles virus infection in the gray and white matter.
寡克隆带表明存在针对该疾病的特异性抗体，可能是由于某些 B 淋巴细胞克隆的激活。这种鞘内免疫球蛋白合成可持续数月至数年，例如，针对副粘病毒、疱疹病毒、柯萨奇病毒和苍白螺旋体；或者可以终生合成，例如在多发性硬化症和亚急性硬化性全脑炎（SSPE）中。我们报告了一例 15 岁男性 SSPE 病例。患者出现胸股区域的肌阵挛性抽搐。必要的实验室检查鉴定出反应性抗麻疹 IgG，这表明之前有麻疹感染或接种疫苗的接触史。本报告描述了寡克隆带在诊断进行性和致命性中枢神经系统 SSPE 中的有用性，该疾病是由于灰、白质中持续的麻疹病毒感染引起的神经退行性疾病。
