Beijing Anzhen Hospital, Capital Medical University, Key Laboratory of Remodeling-related Cardiovascular Diseases, Ministry of Education, Beijing Collaborative Innovation Centre for Cardiovascular Disorders, No. 2 Anzhen Road, Chaoyang District, Beijing 100029, China; Beijing Institute of Heart, Lung and Blood Vessel Disease, No. 2 Anzhen Road, Chaoyang District, Beijing 100029, China.
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, No. 38 Xueyuan Road, Haidian District, Beijing 100083, China; Key Laboratory of Molecular Cardiovascular (Peking University), Ministry of Education, Beijing, China; Center for Real-world Evidence Evaluation, Peking University Clinical Research Institute, Peking University Health Science Center, Peking University, Beijing, China.
J Mol Cell Cardiol. 2022 Oct;171:90-101. doi: 10.1016/j.yjmcc.2022.06.010. Epub 2022 Jul 4.
Aortic aneurysm and dissection (AAD) is a life-threatening medical condition associated with high morbidity and mortality rates. Important mechanisms underlying AAD are the dysregulation of vascular homeostasis and adverse remodeling. Vascular homeostasis maintains normal physiological function. Various physical, chemical, biological, and other internal or external environmental changes dysregulate vascular homeostasis, leading to vascular degeneration and aggravated aortic injury. This process is dependent on the communication between homeostatic mechanisms and the extracellular environment, such as local inflammatory cytokines, vasoactive substances, and hemodynamics. In this article, we summarize recent reports by Chinese researchers who studied the pathogenic mechanisms of AAD mainly from the perspective of communication of the extracellular environment with vascular homeostasis and improving diagnostic methods and therapeutic options for patients with AAD. This review aims to provide a roadmap for AAD that encompasses its pathogenesis and clinical aspects. We hope to facilitate future studies on the development of effective treatments and preventive therapies, and thus improve patient outcomes.
主动脉瘤和夹层（AAD）是一种危及生命的医学病症，与高发病率和死亡率相关。AAD 的重要发病机制是血管稳态失调和不良重构。血管稳态维持正常的生理功能。各种物理、化学、生物和其他内部或外部环境变化会导致血管稳态失调，从而导致血管退化和主动脉损伤加重。这个过程依赖于稳态机制与细胞外环境之间的通讯，如局部炎症细胞因子、血管活性物质和血液动力学。在本文中，我们总结了中国研究人员的最新报告，这些报告主要从细胞外环境与血管稳态的通讯角度研究 AAD 的发病机制，并改善 AAD 患者的诊断方法和治疗选择。这篇综述旨在为 AAD 的发病机制和临床方面提供一个路线图。我们希望为有效治疗和预防疗法的开发提供帮助，从而改善患者的预后。
