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新冠疫情期间经导管主动脉瓣置换术(TAVR)服务的变化:来自英国三级医院的单中心经验。

Changes to transcatheter aortic valve replacement (TAVR) services during the first wave of the COVID-19 pandemic: A single centre experience from United Kingdom tertiary hospital.

机构信息

Trent Cardiac Centre, Nottingham City Hospital, Nottingham University Hospitals NHS Trust, United Kingdom.

Trent Cardiac Centre, Nottingham City Hospital, Nottingham University Hospitals NHS Trust, United Kingdom.

出版信息

Hellenic J Cardiol. 2022 Sep-Oct;67:36-41. doi: 10.1016/j.hjc.2022.07.001. Epub 2022 Jul 4.

Abstract

AIMS

COVID-19 had a devastating impact on patients with severe aortic stenosis (AS). Like many cardiac procedures, transcatheter aortic valve replacement (TAVR) services were suspended during the first wave of COVID-19. We took the opportunity to evaluate the clinical outcomes and identify any delays at different stages of the TAVR pathway during the COVID-19 pandemic.

METHODS

Prospectively collected data on 210 consecutive TAVR patients between March 2019 and March 2021 were analysed. We compared the clinical outcomes and 30-day mortality rates of TAVR cases pre-pandemic and during the pandemic. We also looked to identify any time lags from the initial referral to respective stages of the TAVR workup.

RESULTS

A total of 134 patients underwent TAVR prior to the national lockdown (March 2019-March 2020), compared to 76 patients during COVID-19 (April 2020-April 2021). Success rates of TAVR were similar (99% prior to the pandemic and 97.4% during COVID-19). The 30-day survival rates were 98.6% and 94.7%, respectively. Median length of stay post TAVR was 2 days during COVID-19 and 2.5 days prior to the pandemic (p = 0.064). Patients were seen quicker in clinic (median of 33 days) during COVID-19, compared to 51 days before COVID-19 (p = 0.044). No significant difference in times from referral to discussion at TAVR multidisciplinary team (MDT) meetings, CT Aortogram and TAVR implantation, in both groups.

CONCLUSIONS

Reconfiguring the patient pathway during COVID-19 allowed TAVR to be performed safely, with a similar success rate and no excess complications or increased 30-day mortality. There proved to be no delay in the respective stages of patient TAVR workup, during the pandemic.

摘要

目的

COVID-19 对严重主动脉瓣狭窄(AS)患者造成了毁灭性的影响。与许多心脏手术一样,经导管主动脉瓣置换术(TAVR)服务在 COVID-19 的第一波疫情期间暂停。我们借此机会评估了临床结果,并确定了在 COVID-19 大流行期间 TAVR 途径的不同阶段是否存在任何延误。

方法

前瞻性收集了 2019 年 3 月至 2021 年 3 月期间 210 例连续 TAVR 患者的数据。我们比较了大流行前和大流行期间 TAVR 病例的临床结果和 30 天死亡率。我们还试图确定从最初转诊到 TAVR 检查的各个阶段的任何时间延迟。

结果

共有 134 例患者在全国封锁前(2019 年 3 月至 2020 年 3 月)接受了 TAVR,而在 COVID-19 期间(2020 年 4 月至 2021 年 4 月)有 76 例患者接受了 TAVR。TAVR 的成功率相似(大流行前为 99%,COVID-19 期间为 97.4%)。30 天生存率分别为 98.6%和 94.7%。COVID-19 期间 TAVR 后中位住院时间为 2 天,大流行前为 2.5 天(p=0.064)。COVID-19 期间患者在诊所就诊更快(中位数为 33 天),而 COVID-19 前为 51 天(p=0.044)。两组患者从转诊到 TAVR 多学科团队(MDT)会议、CT 主动脉造影和 TAVR 植入的讨论时间均无明显差异。

结论

在 COVID-19 期间重新配置患者途径可安全地进行 TAVR,成功率相似,无额外并发症或增加 30 天死亡率。在大流行期间,TAVR 患者检查的各个阶段都没有被延迟。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f177/9251899/ea4476892a9b/ga1_lrg.jpg

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