Malandish Abbas, Ghadamyari Niloufar, Karimi Asma, Naderi Mahdi
Ph.D of Exercise Physiology, Department of Exercise Physiology, Faculty of Sport Sciences, Urmia University, Urmia, Iran.
Ph.D Stu. of Exercise Physiology, Department of Exercise Physiology, Faculty of Sport Health Sciences, Ankara University, Ankara, Turkey.
Curr Res Physiol. 2022 Jun 25;5:270-286. doi: 10.1016/j.crphys.2022.06.004. eCollection 2022.
The purpose of this systematic review & meta-analysis was to determine the roles of aerobic, resistance or concurrent exercises vs. control (CON) group on B-type natriuretic peptide (BNP) and N-terminal-pro hormone BNP (NT-proBNP) in patients with heart failure.
The electronic databases of PubMed, Scopus, Web of Science, and Google Scholar were searched up to May 2022 for aerobic vs. CON, resistance vs. CON, and concurrent vs. CON studies on circulating (serum or plasma) levels of BNP and NT-proBNP in patients with heart failure. Non-randomized or randomized controlled trial studies were included. Standardized mean difference (SMD) and 95% confidence intervals (95% CIs) were calculated. This systematic review & meta-analysis was registered in PROSPERO at the University of York with the registration number [CRD42021271632].
A total of 28 articles (37 intervention arms), 26 aerobic intervention arms, 3 resistance intervention arms, and 8 concurrent intervention arms were included. A total of 2563 participants (exercise groups = 1350 and CON groups = 1213) were included. Exercise training significantly decreased NT-proBNP marker [-0.229 (SMD and 95% CI: 0.386 to -0.071), p = 0.005], irrespective of overweight/obesity status. Analysis of subgroup by type of exercise training revealed that there was a significant reduction in the NT-proBNP marker for aerobic exercise group compared to the CON group [-0.336 (SMD and 95% CI: 0.555 to -0.105), p = 0.004], whereas concurrent exercise did not show significant changes in the NT-proBNP marker [-0.134 (SMD and 95% CI: 0.350 to 0.083), p = 0.227]. In addition, exercise training did not significantly change the BNP marker [-0.122 (SMD and 95% CI: 0.322 to 0.079), p = 0.235].
The results suggested that exercise training, especially aerobic exercise can be improved the NT-proBNP concentrations in patients with HF (irrespective of overweight/obesity status), which may be a sign of positive physiological adaptations to aerobic exercise.
本系统评价与荟萃分析的目的是确定有氧运动、抗阻运动或联合运动与对照组相比，对心力衰竭患者B型利钠肽（BNP）和N末端B型利钠肽原（NT-proBNP）的影响。
检索截至2022年5月的PubMed、Scopus、Web of Science和谷歌学术等电子数据库，查找关于心力衰竭患者循环（血清或血浆）BNP和NT-proBNP水平的有氧运动与对照组、抗阻运动与对照组、联合运动与对照组的研究。纳入非随机或随机对照试验研究。计算标准化均数差（SMD）和95%置信区间（95%CI）。本系统评价与荟萃分析已在约克大学的PROSPERO注册，注册号为[CRD42021271632]。
共纳入28篇文章（37个干预组），其中26个有氧运动干预组、3个抗阻运动干预组和8个联合运动干预组。共纳入2563名参与者（运动组=1350名，对照组=1213名）。运动训练显著降低了NT-proBNP指标[-0.229（SMD和95%CI：0.386至-0.071），p=0.005]，无论超重/肥胖状态如何。按运动训练类型进行亚组分析显示，与对照组相比，有氧运动组的NT-proBNP指标显著降低[-0.336（SMD和95%CI：0.555至-0.105），p=0.004]，而联合运动组的NT-proBNP指标未显示出显著变化[-0.134（SMD和95%CI：0.350至0.083），p=0.227]。此外，运动训练对BNP指标无显著影响[-0.122（SMD和95%CI：0.322至0.079），p=0.235]。
结果表明，运动训练，尤其是有氧运动，可以改善心力衰竭患者的NT-proBNP浓度（无论超重/肥胖状态如何），这可能是对有氧运动产生积极生理适应的一个标志。
