Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
National Health Commission of the People's Republic of China (NHC) Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Front Cell Infect Microbiol. 2022 Jun 21;12:814668. doi: 10.3389/fcimb.2022.814668. eCollection 2022.
Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases. After studying 602 unvaccinated Chinese women using 16S rRNA to detect cervical-vaginal microecology, we analyzed the relationship between HPV infection and vaginal microecology including 20 HPV types. In Chinese women, dominated and dominated clusters were significantly absence. Microbial alpha diversity was significantly higher in HPV-infected and cervical intraepithelial neoplasia (CIN)-diagnosed groups than in healthy control group. Certain bacteria were associated with HPV infection and CIN, including , , , , , and With the development of disease, the proportions of community state type III (CST-III) and CST-IV-B gradually increased, whereas the proportions of CST-I and CST-IV-A gradually decreased. In addition, age was an influential factor for HPV infection. With aging, the probability of HPV infection and the proportion of CST-IV-B increase. In conclusion, our study was a large cross-sectional study that evaluated the relationship between vaginal microbiota and HPV infection, and brought essential comparable data.
人乳头瘤病毒（HPV）感染是最常见的性传播疾病之一。本研究使用 16S rRNA 检测了 602 名未接种疫苗的中国女性的宫颈阴道微生态，分析了包括 20 种 HPV 型在内的 HPV 感染与阴道微生态的关系。在中国女性中，优势和优势菌群明显缺失。HPV 感染和宫颈上皮内瘤变（CIN）诊断组的微生物 α 多样性明显高于健康对照组。某些细菌与 HPV 感染和 CIN 相关，包括 、 、 、 、 、 和 。随着疾病的发展，社区状态类型 III（CST-III）和 CST-IV-B 的比例逐渐增加，而 CST-I 和 CST-IV-A 的比例逐渐减少。此外，年龄是 HPV 感染的一个影响因素。随着年龄的增长，HPV 感染的概率和 CST-IV-B 的比例增加。总之，本研究是一项大型横断面研究，评估了阴道微生物群与 HPV 感染之间的关系，并提供了重要的可比数据。
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