Slavkova N, Nedevska M
Department of diagnostic imaging, University Hospital "St. Ekaterina", Medical University, Pencho Slaveikov 52A, 143, Sofia, Bulgaria.
Radiol Case Rep. 2022 Jul 2;17(9):3228-3232. doi: 10.1016/j.radcr.2022.06.009. eCollection 2022 Sep.
The course of the new SARS-CoV-2 (COVID-19) is unpredictable and is still being investigated. Although the majority of complications are expected to affect the respiratory system, there have been reports in literature concerning the adverse effects of the infection on bone and joint tissue. Several complications have been observed in the maxillofacial area in people who suffered from the infection, including osteonecrosis and osteomyelitis of the jaw. These complications have been subject to various hypotheses. They may result either from the disease pathogenetic mechanism or from a response to the therapeutic modalities used to treat the underlying disease, and overuse of particular medications - glucocorticoids, antirheumatics, interleukin-6 inhibitors, and antibiotics. This article presents a case of osteonecrosis of the maxilla after severe COVID-19 infection.
新型严重急性呼吸综合征冠状病毒2（SARS-CoV-2，即新冠病毒）感染的病程难以预测，仍在研究之中。尽管大多数并发症预计会影响呼吸系统，但文献中已有关于该感染对骨骼和关节组织产生不良影响的报道。在感染新冠病毒的患者中，颌面区域观察到了几种并发症，包括颌骨坏死和骨髓炎。这些并发症存在多种假说。它们可能源于疾病的发病机制，也可能是对用于治疗基础疾病的治疗方式的反应，以及特定药物（糖皮质激素、抗风湿药、白细胞介素-6抑制剂和抗生素）的过度使用。本文介绍了一例严重新冠病毒感染后上颌骨坏死的病例。
