Division of Food, Nutrition and Exercise Sciences, University of Missouri, 1406 E Rollins Street, Columbia, MO, 65211, USA.
Food Funct. 2022 Aug 1;13(15):7960-7983. doi: 10.1039/d2fo01298g.
Exposure to toxins is a severe threat to human health and life in today's developing and industrialized world. Therefore, identifying a protective chemical could be valuable and fascinating in this case. The purpose of this article was to bring together thorough review of studies on to aid in the creation of ways for delivering its phytoconstituents to treat toxicants and radiation. This review gathered and evaluated studies on the defensive impact of extract (GBE) against toxicities caused by toxic chemical agents (such as lead, cadmium, and aluminum), natural toxins (for example, lipopolysaccharide-induced toxicity and damage, gossypol, latadenes, and lotaustralin), and radiation (for example, gamma, ultra-violet, and radio-frequency radiation). According to this review, GBE has a considerable therapeutic effect by influencing specific pathophysiological targets. Furthermore, GBE has antioxidant, anti-inflammatory, anti-apoptotic, and antigenotoxicity properties against various toxicities. These are due to flavone glycosides (primarily isorhamnetin, kaempferol, and quercetin) and terpene trilactones (ginkgolides A, B, C, and bilobalide) that aid GBEs' neutralizing effect against radiation and toxins by acting independently or synergistically. This will serve as a reference for the functional food, cosmetic, and pharmaceutical industries worldwide.
在当今发展中国家和工业化世界，接触毒素对人类健康和生命构成严重威胁。因此，在这种情况下，确定一种保护化学物质可能具有重要意义和吸引力。本文的目的是汇集关于 的研究综述，以帮助寻找将其植物成分递送至治疗毒物和辐射的方法。本综述收集和评估了 提取物 (GBE) 对有毒化学物质（如铅、镉和铝）、天然毒素（如脂多糖诱导的毒性和损伤、棉酚、拉坦丁和洛塔斯特林）以及辐射（如γ、紫外线和射频辐射）引起的毒性的防御作用的研究。根据这项综述，GBE 通过影响特定的病理生理靶点，具有相当大的治疗效果。此外，GBE 具有抗氧化、抗炎、抗细胞凋亡和抗遗传毒性特性，可抵抗各种毒性。这是由于类黄酮糖苷（主要是异鼠李素、山奈酚和槲皮素）和三萜内酯（银杏内酯 A、B、C 和白果内酯），它们通过独立或协同作用，帮助 GBE 对辐射和毒素产生中和作用。这将为全球的功能性食品、化妆品和制药行业提供参考。
