Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.
Department of Internal Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
Medicine (Baltimore). 2022 Jul 8;101(27):e29884. doi: 10.1097/MD.0000000000029884.
Recently, a novel oral sulfate tablet (OST) has been introduced for bowel preparation before colonoscopy. However, whether elderly patients can take OST is not yet clear, as OST consists of 28 tablets. We aimed to compare the efficacy and safety of OST and polyethylene glycol (PEG) for bowel preparation for colonoscopy according to age.
We randomly divided subjects into an OST group and a PEG group and compared Boston Bowel Preparation Score (BBPS), bubble score, patient compliance and satisfaction, and safety between the 2 groups according to age (under 65 years of age vs 65 years of age and older).
Among the 179 participants, 61 were 65 years of age and older. The BBPS and bubble score of the OST group were better than that of the PEG group, regardless of age. The satisfaction of the OST group was better than that of the PEG group, regardless of age. The compliance was not different between the 2 groups; however, the OST group under 65 years of age had a higher rate of completing the dose within 2 hours compared with the PEG group under 65 years of age. Adverse events including abdominal distension, abdominal pain, nausea, or vomiting were not different between the 2 groups.
The use of OST for bowel preparation before colonoscopy is as effective and safe as PEG, and these results were consistent in elderly people 65 years of age and older.
最近，一种新型口服硫酸盐片（OST）已被用于结肠镜检查前的肠道准备。然而，老年人是否可以服用 OST 尚不清楚，因为 OST 由 28 片组成。我们旨在根据年龄比较 OST 和聚乙二醇（PEG）在结肠镜检查肠道准备中的疗效和安全性。
我们将受试者随机分为 OST 组和 PEG 组，并根据年龄（<65 岁与≥65 岁）比较两组之间波士顿肠道准备评分（BBPS）、气泡评分、患者依从性和满意度以及安全性。
在 179 名参与者中，有 61 名年龄在 65 岁及以上。无论年龄大小，OST 组的 BBPS 和气泡评分均优于 PEG 组。无论年龄大小，OST 组的满意度均优于 PEG 组。两组之间的依从性没有差异；然而，<65 岁的 OST 组完成 2 小时内剂量的比例高于<65 岁的 PEG 组。两组之间不良反应（包括腹胀、腹痛、恶心或呕吐）无差异。
OST 用于结肠镜检查前肠道准备与 PEG 一样有效且安全，这些结果在 65 岁及以上的老年人中是一致的。
