Park Jin Hwa, Kim Minjun, Hong Seung Wook, Hwang Sung Wook, Park Sang Hyoung, Yang Dong-Hoon, Ye Byong Duk, Myung Seung-Jae, Yang Suk-Kyun, Byeon Jeong-Sik
Department of Gastroenterology, University of Hanyang College of Medicine, 222-1, Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea.
Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea.
J Clin Med. 2024 Dec 9;13(23):7493. doi: 10.3390/jcm13237493.
A low-volume (1 L) polyethylene glycol plus ascorbic acid (PEG-A) solution and an oral sodium sulfate tablet (OST) formulation are recently introduced agents for colonoscopy bowel preparation. This study investigated the efficacy, safety, and tolerability of 1 L PEG-A vs. OST. This single-center, prospective, randomized, endoscopist-blinded study randomly assigned patients into 2 groups: 1 L PEG-A (group A); and OST (group B). Efficacy of bowel preparation was evaluated using the Boston Bowel Preparation Scale (BBPS). Tolerability and safety were investigated with a standardized questionnaire. A total of 174 patients were included in the final analysis (group A, n = 92; group B, n = 82). Successful bowel preparation was achieved in 91.3% and 95.1% of patients in groups A and B, respectively ( = 0.324). Overall mean satisfaction with bowel preparation was greater among those in group B vs. those in group A (8.2 ± 1.7 vs. 6.8 ± 2.0, respectively; < 0.001). Although abdominal distension was less common in group A than group B (3/92 [3.3%] vs. 9/82 [11.0%], respectively; = 0.045), overall adverse events developed similarly in both groups (27/92 [29.3%] vs. 21/82 [25.6%], = 0.583). In subgroup analysis of older patients (≥65 years of age), efficacy, overall satisfaction, and safety profiles were not different between groups A and B. Both 1 L PEG-A and OST demonstrated efficacy, tolerability, and safety for colonoscopy bowel preparation. OST was slightly better tolerated, whereas 1 L PEG-A resulted in less abdominal distension. Both agents were effective and safe in older patients.
一种小容量（1升）的聚乙二醇加抗坏血酸（PEG-A）溶液和口服硫酸钠片（OST）制剂是最近推出的用于结肠镜检查肠道准备的药物。本研究调查了1升PEG-A与OST的疗效、安全性和耐受性。这项单中心、前瞻性、随机、内镜医师盲法研究将患者随机分为两组：1升PEG-A组（A组）；和OST组（B组）。使用波士顿肠道准备量表（BBPS）评估肠道准备的疗效。通过标准化问卷调查耐受性和安全性。最终分析共纳入174例患者（A组，n = 92；B组，n = 82）。A组和B组分别有91.3%和95.1%的患者成功完成肠道准备（P = 0.324）。B组患者对肠道准备的总体平均满意度高于A组（分别为8.2±1.7和6.8±2.0；P < 0.001）。虽然A组腹胀的发生率低于B组（分别为3/92 [3.3%]和9/82 [11.0%]；P = 0.045），但两组总体不良事件的发生情况相似（27/92 [29.3%]和21/82 [25.6%]，P = 0.583）。在老年患者（≥65岁）的亚组分析中，A组和B组在疗效、总体满意度和安全性方面无差异。1升PEG-A和OST在结肠镜检查肠道准备中均显示出疗效、耐受性和安全性。OST的耐受性稍好，而1升PEG-A导致的腹胀较少。两种药物在老年患者中均有效且安全。
