Department of Neuroscience, Reproductive Sciences and Odontostomatology, Headache Centre, University Federico II of Naples, Via Pansini, 5, 80122, Naples, Italy.
Neurol Sci. 2022 Sep;43(9):5665-5672. doi: 10.1007/s10072-022-06200-x. Epub 2022 Jul 8.
Besides representing the place where a migraine attack generates, what is the physiological role of peptidergic control of arteriolar caliber within the trigemino-vascular system? Considering that the shared goal of most human CGRP-based neurosensory systems is the protection from an acute threat, especially if hypoxic, what is the end meaning of a migraine attack? In this paper, we have reviewed available evidence on the possible role of the trigemino-vascular system in maintaining cerebral perfusion pressure homeostasis, despite the large physiological fluctuations in intracranial pressure occurring in daily life activities. In this perspective, the migraine attack is presented as the response to a cerebral hypoxic threat consequent to a deranged intracranial pressure control aimed at generating a temporary withdrawal from the environment with limitation of physical activity, a condition required to promote the restoration of cerebral fluids dynamic balance.
除了代表偏头痛发作的发生部位，三叉血管系统中肽能控制动脉血管口径的生理作用是什么？考虑到大多数基于 CGRP 的人类神经感觉系统的共同目标是防止急性威胁，特别是缺氧，如果是缺氧，偏头痛发作的最终意义是什么？在本文中，我们回顾了三叉血管系统在维持脑灌注压平衡方面的可能作用的现有证据，尽管在日常生活活动中颅内压会发生较大的生理波动。从这个角度来看，偏头痛发作是对缺氧威胁的反应，这种缺氧是由于颅内压控制失调引起的，其目的是暂时脱离环境，限制体力活动，这是促进脑液动力学平衡恢复所必需的条件。
