Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, 127 Changle West Road, Xi'an, 710032, Shaanxi Province, China.
Stem Cell Rev Rep. 2022 Aug;18(6):2002-2015. doi: 10.1007/s12015-022-10404-1. Epub 2022 Jul 8.
Hair follicle stem cells (HFSCs) are derived from the bulge region and are important autologous stem cell sources. Bibliometric is a statistical method that quantitatively analyses the research papers concerned about one special topic. This study aims to estimate the research status and trends of HFSCs worldwide by bibliometric analyses.
Data were obtained from the Web of Science by searching keywords related to HFSCs. Publication distributions stratified by countries/regions, institutions, journals, and authors were systematically assessed. The frequency of keywords was assessed, and bibliometric mapping was employed to describe the development of HFSC research.
A total of 458 publications that met our screening criteria were included in this study, consisting of 423 (92.4%) articles and 35 (7.6%) reviews. The United States of America (USA) ranked first in the number of publications at 146 (31.9%), followed by China at 130 (28.4%), which is consistent with the rank of the H-index. Author keywords were classified into three clusters, namely, basic study, applied study, and biomarker; average publication time of keywords in applied study cluster is later than basic study cluster. The keywords "bulge", "nestin", and "skin" are the top three most frequent keywords in basic studies; "differentiation", "proliferation", and "alopecia" are the top three most frequent keywords in applied studies. With respect to the latest research hotspots, "apoptosis" and "tissue engineering" are relatively new keywords.
The USA and China were the most productive countries for research on HFSCs. The focus of keywords gradually shifted from basic study to applied study. Research on the differentiation/proliferation of HFSCs and the role of HFSCs in alopecia have been recent research focuses. Apoptosis and tissue engineering are recommended as promising research hotspots. Our study provides profound insights into the research history, current status, and future trend of HFSCs.
毛囊干细胞（HFSCs）来源于毛囊隆突区，是重要的自体干细胞来源。文献计量学是一种统计方法，可以定量分析有关特定主题的研究论文。本研究旨在通过文献计量学分析评估全球 HFSCs 的研究现状和趋势。
通过在 Web of Science 上搜索与 HFSCs 相关的关键词获取数据。系统评估了按国家/地区、机构、期刊和作者划分的出版物分布情况。评估了关键词的频率，并采用文献计量制图法描述 HFSC 研究的发展情况。
本研究共纳入符合筛选标准的 458 篇出版物，包括 423 篇（92.4%）文章和 35 篇（7.6%）综述。美国在出版物数量上排名第一（146 篇，31.9%），其次是中国（130 篇，28.4%），这与 H 指数的排名一致。作者关键词分为基础研究、应用研究和生物标志物三个聚类；应用研究聚类中关键词的平均发表时间晚于基础研究聚类。基础研究中最常出现的三个关键词是“隆突”“巢蛋白”和“皮肤”；应用研究中最常出现的三个关键词是“分化”“增殖”和“脱发”。关于最新的研究热点，“凋亡”和“组织工程”是相对较新的关键词。
美国和中国是 HFSCs 研究最活跃的国家。关键词的重点逐渐从基础研究转移到应用研究。HFSCs 的分化/增殖研究以及 HFSCs 在脱发中的作用一直是近期的研究重点。凋亡和组织工程被推荐为有前途的研究热点。本研究深入了解了 HFSCs 的研究历史、现状和未来趋势。
