Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.
School of Pharmaceutical Sciences, Hebei University of Chinese Medicine, Shijiazhuang 050091, China.
Molecules. 2023 Jul 17;28(14):5456. doi: 10.3390/molecules28145456.
Four new meroterpenoids, Clavilactone M-P, possessing novel aminoglycoside moiety (-) and a 10-membered carbocycle fused with an α,β-epoxy-γ-lactone, were isolated from , a basidiomycete. Their structures with absolute configurations were determined by extensive analysis of their spectroscopic data, and the ECD method. All the isolated compounds (-) were evaluated for their antitumor activity against three human cancer cell lines using the MTT assay. Compound and exhibited a significant suppression of cell viability in the Hela (IC = 22.8 and 19.7 μM) cell line.
四种新的倍半萜类化合物，Clavilactone M-P，具有新颖的氨基糖苷部分（-）和与α，β-环氧-γ-内酯融合的 10 元碳环，从担子菌中分离得到。通过对其光谱数据和 ECD 方法的广泛分析，确定了它们的结构和绝对构型。所有分离出的化合物（-）均通过 MTT 法评估了对三种人癌细胞系的抗肿瘤活性。化合物和在 Hela（IC = 22.8 和 19.7 μM）细胞系中表现出显著的抑制细胞活力。
