表面特性以及胶体颗粒与小鼠腹腔巨噬细胞的相互作用。
Surface characteristics and the interaction of colloidal particles with mouse peritoneal macrophages.
作者信息
Illum L, Jacobsen L O, Müller R H, Mak E, Davis S S
出版信息
Biomaterials. 1987 Mar;8(2):113-7. doi: 10.1016/0142-9612(87)90099-8.
The effect of surface characteristics on the interaction of sterically stabilized polystyrene particles with mouse peritoneal macrophages was studied using a range of poloxamers and poloxamine as coating agents. The coated particles were characterized in terms of thickness of coating layer, surface charge and critical flocculation temperature. The relative phagocytic uptake was found to decrease with increasing adsorbed layer thickness i.e. longer hydrophilic polymer chains of the coating agent and consequently a greater steric stabilization effect.
使用一系列泊洛沙姆和泊洛胺作为包衣剂，研究了表面特性对空间稳定的聚苯乙烯颗粒与小鼠腹膜巨噬细胞相互作用的影响。对包衣颗粒的包衣层厚度、表面电荷和临界絮凝温度进行了表征。发现相对吞噬摄取量随着吸附层厚度的增加而降低，即包衣剂的亲水性聚合物链更长，从而产生更大的空间稳定效应。
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