Biology of Organisms: Stress, Health, Environment (BiOSSE), UFR Sciences et Techniques, Le Mans Université, F-72085 Le Mans, France.
Biology of Organisms: Stress, Health, Environment (BiOSSE), Institut Universitaire de Technologie, Département Génie Biologique, Le Mans Université, F-53020 Laval, France.
Int J Environ Res Public Health. 2022 Jun 28;19(13):7936. doi: 10.3390/ijerph19137936.
Nowadays, diet and breast cancer are studied at different levels, particularly in tumor prevention and progression. Thus, the molecular mechanisms leading to better knowledge are deciphered with a higher precision. Among the molecules implicated in a preventive and anti-progressive way, n-3 long chain polyunsaturated fatty acids (n-3 LC-PUFAs) are good candidates. These molecules, like docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids, are generally found in marine material, such as fat fishes or microalgae. EPA and DHA act as anti-proliferative, anti-invasive, and anti-angiogenic molecules in breast cancer cell lines, as well as in in vivo studies. A better characterization of the cellular and molecular pathways involving the action of these fatty acids is essential to have a realistic image of the therapeutic avenues envisaged behind their use. This need is reinforced by the increase in the number of clinical trials involving more and more n-3 LC-PUFAs, and this, in various pathologies ranging from obesity to a multitude of cancers. The objective of this review is, therefore, to highlight the new elements showing the preventive and beneficial effects of n-3 LC-PUFAs against the development and progression of breast cancer.
如今，饮食与乳腺癌在不同层面上受到研究，尤其是在肿瘤预防和进展方面。因此，人们以更高的精度揭示了导致更好认识的分子机制。在以预防和阻止进展方式起作用的分子中，n-3 长链多不饱和脂肪酸（n-3 LC-PUFAs）是很好的候选物。这些分子，如二十二碳六烯酸（DHA）和二十碳五烯酸（EPA），通常存在于海洋物质中，如脂肪鱼或微藻。EPA 和 DHA 作为抗增殖、抗侵袭和抗血管生成分子，在乳腺癌细胞系以及体内研究中发挥作用。更好地描述涉及这些脂肪酸作用的细胞和分子途径，对于了解它们的使用所设想的治疗途径是至关重要的。随着涉及越来越多的 n-3 LC-PUFAs 的临床试验数量的增加，这种需求得到了加强，这些临床试验涉及从肥胖到多种癌症等各种病症。因此，本综述的目的是强调显示 n-3 LC-PUFAs 对乳腺癌发生和发展的预防和有益作用的新元素。
