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白藜芦醇对纳米氧化铁诱导的成年雄性大鼠睾丸组织氧化应激和类固醇生成相关基因失调的缓解作用。

Palliative Effect of Resveratrol against Nanosized Iron Oxide-Induced Oxidative Stress and Steroidogenesis-Related Genes Dysregulation in Testicular Tissue of Adult Male Rats.

机构信息

Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 4511, Egypt.

Department of Biochemistry, Faculty of Veterinary Medicine, Zagazig University, Zagazig 4511, Egypt.

出版信息

Int J Environ Res Public Health. 2022 Jul 4;19(13):8171. doi: 10.3390/ijerph19138171.

DOI:10.3390/ijerph19138171
PMID:35805830
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9266693/
Abstract

The nano-sized iron oxide (FeO-NPs) is one of the most used engineered nanomaterials worldwide. This study investigated the efficacy of natural polyphenol resveratrol (RSV) (20 mg/kg b.wt, orally once daily) to alleviate the impaired sperm quality and testicular injury resulting from FeO-NPs exposure (3.5 or 7 mg/kg b.wt, intraperitoneally once a week) for eight weeks. Spermiograms, sexual hormonal levels, oxidative stress indicators, and lipid peroxidation biomarker were assessed. Moreover, the steroidogenesis-related genes mRNA expressions were evaluated. The results showed that RSV substantially rescued FeO-NPs-mediated sperm defects. Additionally, the FeO-NPs-induced depressing effects on sperm motility and viability were markedly counteracted by RSV. Moreover, RSV significantly restored FeO-NPs-induced depletion of testosterone, follicle-stimulated hormone, luteinizing hormone, and testicular antioxidant enzymes but reduced malondialdehyde content. Furthermore, the FeO-NPs-induced downregulation of steroidogenesis-related genes (3 β-HSD, 17 β-HSD, and Nr5A1) was significantly counteracted in the testicular tissue of RSV-treated rats. These findings concluded that RSV could limit the FeO-NPs-induced reduced sperm quality and testicular injury most likely via their antioxidant activity and steroidogenesis-related gene expression modulation.

摘要

纳米级氧化铁 (FeO-NPs) 是全球应用最广泛的工程纳米材料之一。本研究旨在探讨天然多酚白藜芦醇 (RSV)（20mg/kg bw，口服，每天一次）对减轻 FeO-NPs 暴露（3.5 或 7mg/kg bw，每周腹腔注射一次）引起的精子质量受损和睾丸损伤的功效，为期 8 周。评估精子参数、性激素水平、氧化应激指标和脂质过氧化生物标志物，同时评估类固醇生成相关基因的 mRNA 表达。结果表明，RSV 可显著改善 FeO-NPs 介导的精子缺陷。此外，RSV 明显拮抗了 FeO-NPs 对精子活力和活力的抑制作用。此外，RSV 显著恢复了 FeO-NPs 诱导的睾丸中睾酮、卵泡刺激素、黄体生成素和抗氧化酶的耗竭，但降低了丙二醛含量。此外，RSV 还可拮抗 FeO-NPs 诱导的类固醇生成相关基因（3β-HSD、17β-HSD 和 Nr5A1）下调。这些发现表明 RSV 可能通过其抗氧化活性和类固醇生成相关基因表达调节，限制 FeO-NPs 诱导的精子质量下降和睾丸损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dfa/9266693/1c29791a4e72/ijerph-19-08171-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dfa/9266693/38d2a1d47637/ijerph-19-08171-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dfa/9266693/ab2f0c65c863/ijerph-19-08171-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dfa/9266693/a41b07368198/ijerph-19-08171-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dfa/9266693/50facfcf6812/ijerph-19-08171-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dfa/9266693/17d7d65301fb/ijerph-19-08171-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dfa/9266693/1c29791a4e72/ijerph-19-08171-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dfa/9266693/38d2a1d47637/ijerph-19-08171-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dfa/9266693/ab2f0c65c863/ijerph-19-08171-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dfa/9266693/a41b07368198/ijerph-19-08171-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dfa/9266693/50facfcf6812/ijerph-19-08171-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dfa/9266693/17d7d65301fb/ijerph-19-08171-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dfa/9266693/1c29791a4e72/ijerph-19-08171-g006.jpg

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引用本文的文献

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Cells. 2025-7-21

[2]
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[5]
Influence of titanium dioxide nanoparticles and/or cadmium chloride oral exposure on testicular morphology, oxidative stress, and apoptosis in rats: Ameliorative role of co-enzyme Q10.

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[6]
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[7]
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本文引用的文献

[1]
Effects of Co-Exposure of Nanoparticles and Metals on Different Organisms: A Review.

Toxics. 2021-11-1

[2]
Metal Oxide Nanoparticles: Evidence of Adverse Effects on the Male Reproductive System.

Int J Mol Sci. 2021-7-28

[3]
Iprodione and/or chlorpyrifos exposure induced testicular toxicity in adult rats by suppression of steroidogenic genes and SIRT1/TERT/PGC-1α pathway.

Environ Sci Pollut Res Int. 2021-10

[4]
Quercetin Attenuates Brain Oxidative Alterations Induced by Iron Oxide Nanoparticles in Rats.

Int J Mol Sci. 2021-4-7

[5]
Iprodione and chlorpyrifos induce testicular damage, oxidative stress, apoptosis and suppression of steroidogenic- and spermatogenic-related genes in immature male albino rats.

Andrologia. 2021-5

[6]
Resveratrol and Neuroprotection: Impact and Its Therapeutic Potential in Alzheimer's Disease.

Front Pharmacol. 2020-12-30

[7]
Chitosan-Stabilized Selenium Nanoparticles and Metformin Synergistically Rescue Testicular Oxidative Damage and Steroidogenesis-Related Genes Dysregulation in High-Fat Diet/Streptozotocin-Induced Diabetic Rats.

Antioxidants (Basel). 2020-12-27

[8]
The Modulatory Role of Vitamin C in Boldenone Undecylenate Induced Testicular Oxidative Damage and Androgen Receptor Dysregulation in Adult Male Rats.

Antioxidants (Basel). 2020-10-28

[9]
Therapeutic potential of resveratrol against emerging respiratory viral infections.

Pharmacol Ther. 2020-6-17

[10]
The protective effects of pretreatment with resveratrol in cyclophosphamide-induced rat ovarian granulosa cell injury: In vitro study.

Reprod Toxicol. 2020-8

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