Cristescu Carmen Valentina, Alain Sophie, Ruță Simona Maria
School of Advanced Studies of the Romanian Academy (SCOSAAR), Romanian Academy, 010071 Bucharest, Romania.
National Center for Cytomegalovirus Research, UMR 1092, 87042 Limoges, France.
J Clin Med. 2022 Jul 1;11(13):3832. doi: 10.3390/jcm11133832.
The number of deaths related to cardiovascular disease is increasing every year, despite all available therapies and the aggressive campaigns for lifestyle modification and prevention of risk factors. Atherosclerosis is a complex process underlying cardiovascular disease. Cytomegalovirus (CMV) is often associated to atherosclerosis and its clinical expression such as coronary heart disease, stroke, or peripheral artery disease. CMV infection may promote acute atherosis within placentas from women with preeclampsia and it may also accelerate atherosclerosis in HIV-infected and organ-transplanted patients. This review focuses on the current scientific evidence for the role of CMV infection in the development of acute atherosis and atherosclerosis from placentation throughout life.
尽管有各种可用的治疗方法以及积极开展的生活方式改变和危险因素预防运动，但与心血管疾病相关的死亡人数仍在逐年增加。动脉粥样硬化是心血管疾病的一个复杂潜在过程。巨细胞病毒（CMV）常与动脉粥样硬化及其临床表现如冠心病、中风或外周动脉疾病相关。CMV感染可能促进子痫前期女性胎盘内的急性动脉粥样硬化，也可能加速HIV感染患者和器官移植患者的动脉粥样硬化进程。本综述聚焦于CMV感染在从胎盘形成到整个生命过程中急性动脉粥样硬化和动脉粥样硬化发展中所起作用的当前科学证据。
