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异黄酮通过 PPARγ 保护糖尿病去卵巢大鼠的肾脏组织。

Isoflavone Protects the Renal Tissue of Diabetic Ovariectomized Rats via PPARγ.

机构信息

Structural and Functional Biology Graduate Program, Paulista School of Medicine, Federal University of São Paulo (EPM/UNIFESP), 740 Edifício Lemos Torres-2° andar, Vila Clementino, São Paulo 04023-900, SP, Brazil.

Department of Gynecology, Paulista School of Medicine, Federal University of São Paulo (EPM/UNIFESP), São Paulo 04023-900, SP, Brazil.

出版信息

Nutrients. 2022 Jun 21;14(13):2567. doi: 10.3390/nu14132567.

DOI:10.3390/nu14132567
PMID:35807748
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9268059/
Abstract

Diabetes associated with post-menopause is related to a worse condition of kidney disease. Taking into consideration that this disorder may be regulated by estrogenic mediators, we evaluated the renal protective effect of isoflavone. We investigated the role of the PPARγ in the pathogenesis of the disease. For this study, we used diabetic female rats in a postmenopausal model through ovariectomy. The animals were treated with isoflavone or 17β-estradiol. A dosage was administered to bring on blood glycemia, and through immunohistochemistry, we evaluated the immunoreactivity of PPARγ in the endometrium and renal tissue. We analyzed the immunoreactivity of renal injury molecule KIM-1 and the collagen and glycogen densities in the kidney. Through bioinformatics analysis, we observed and gene expression under the influence of different glucose doses. In particular, we observed that isoflavone and 17β-estradiol regulate blood glycemia. Renal injury was inhibited by isoflavone, observed by a reduction in KIM-1, along with glycogen accumulation. These benefits of isoflavone may be associated with PPARγ overexpression in the kidneys and endometrium of diabetic ovariectomized rats.

摘要

绝经后与糖尿病相关的疾病与肾脏疾病的恶化状况有关。考虑到这种疾病可能受雌激素介质调节，我们评估了异黄酮的肾脏保护作用。我们研究了 PPARγ 在疾病发病机制中的作用。在这项研究中，我们使用了去卵巢的绝经后糖尿病雌性大鼠模型。动物用异黄酮或 17β-雌二醇治疗。给予一定剂量以控制血糖，并通过免疫组织化学评估子宫内膜和肾组织中 PPARγ 的免疫反应性。我们分析了肾损伤分子 KIM-1 的免疫反应性以及肾脏中胶原和糖原的密度。通过生物信息学分析，我们观察了不同葡萄糖剂量下 和 基因的表达。特别是，我们观察到异黄酮和 17β-雌二醇调节血糖。通过减少 KIM-1 观察到异黄酮抑制了肾损伤，同时伴随着糖原积累。这些异黄酮的益处可能与糖尿病去卵巢大鼠肾脏和子宫内膜中 PPARγ 的过表达有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/128e/9268059/c52a7c20b33f/nutrients-14-02567-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/128e/9268059/d6832cd411ea/nutrients-14-02567-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/128e/9268059/d6832cd411ea/nutrients-14-02567-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/128e/9268059/7ee44f4e06ae/nutrients-14-02567-g002.jpg
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Tinospora cordifolia activates PPARγ pathway and mitigates glomerular and tubular cell injury in diabetic kidney disease.
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