Department of Geriatrics and Orthopedics, Università Cattolica del Sacro Cuore, L.go F. Vito 1, 00168 Rome, Italy.
Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, L.go A. Gemelli 8, 00168 Rome, Italy.
Nutrients. 2022 Jul 5;14(13):2767. doi: 10.3390/nu14132767.
The present systematic review and meta-analysis investigated the cross-sectional and longitudinal associations between protein intake and frailty in older adults.
We conducted a systematic review and meta-analysis of cross-sectional and longitudinal studies that investigated the association between protein intake and frailty in older adults. Cross-sectional, case-control, and longitudinal cohort studies that investigated the association between protein intake and frailty as a primary or secondary outcome in people aged 60+ years were included. Studies published in languages other than English, Italian, Portuguese, or Spanish were excluded. Studies were retrieved on 31 January 2022.
Twelve cross-sectional and five longitudinal studies that investigated 46,469 community-dwelling older adults were included. The meta-analysis indicated that absolute, bodyweight-adjusted, and percentage of protein relative to total energy consumption were not cross-sectionally associated with frailty. However, frail older adults consumed significantly less animal-derived protein than robust people. Finally, high protein consumption was associated with a significantly lower risk of frailty.
Our pooled analysis indicates that protein intake, whether absolute, adjusted, or relative to total energy intake, is not significantly associated with frailty in older adults. However, we observed that frail older adults consumed significantly less animal protein than their robust counterparts.
本系统评价和荟萃分析调查了蛋白质摄入量与老年人虚弱之间的横断面和纵向关联。
我们对横断面和纵向研究进行了系统评价和荟萃分析，这些研究调查了老年人蛋白质摄入量与虚弱之间的关联。纳入了研究蛋白质摄入量与虚弱作为 60 岁及以上人群主要或次要结局之间关联的横断面、病例对照和纵向队列研究。排除了非英语、意大利语、葡萄牙语或西班牙语发表的研究。研究于 2022 年 1 月 31 日检索。
纳入了 12 项横断面研究和 5 项纵向研究，共纳入 46469 名社区居住的老年人。荟萃分析表明，绝对、体重校正和相对于总能量消耗的蛋白质百分比与虚弱不呈横断面相关。然而，虚弱的老年人摄入的动物源性蛋白质明显少于健壮的人。最后，高蛋白质摄入与虚弱的风险显著降低相关。
我们的汇总分析表明，蛋白质摄入量，无论是绝对的、调整后的还是相对于总能量摄入，与老年人的虚弱都没有显著关联。然而，我们观察到虚弱的老年人摄入的动物蛋白明显少于健壮的同龄人。
