Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Department of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia.
Molecules. 2023 Feb 23;28(5):2095. doi: 10.3390/molecules28052095.
The remarkable properties of nickel oxide (NiO) and cerium oxide (CeO) nanostructures have attracted considerable interest in these nanocomposites as potential electroactive materials for sensor construction.
The mebeverine hydrochloride (MBHCl) content of commercial formulations was determined in this study using a unique factionalized CeO/NiO-nanocomposite-coated membrane sensor.
Mebeverine-phosphotungstate (MB-PT) was prepared by adding phosphotungstic acid to mebeverine hydrochloride and mixing with a polymeric matrix (polyvinyl chloride, PVC) and plasticizing agent -nitrophenyl octyl ether. The new suggested sensor showed an excellent linear detection range of the selected analyte at 1.0 × 10-1.0 × 10 mol L with regression equation E = (-29.429 0.2) log [MB] + 347.86. However, the unfunctionalized sensor MB-PT displayed less linearity at 1.0 × 101.0 × 10 mol L drug solution with regression equation E = (-26.603 ± 0.5) log [MB] + 256.81. By considering a number of factors, the applicability and validity of the suggested potentiometric system were improved following the rules of analytical methodological requirements.
The created potentiometric technique worked well for determining MB in bulk substance and in medical commercial samples.
氧化镍（NiO）和氧化铈（CeO）纳米结构的显著特性引起了人们对这些纳米复合材料的极大兴趣，因为它们是构建传感器的潜在电活性材料。
本研究采用独特的分形 CeO/NiO 纳米复合材料涂层膜传感器，测定市售制剂中盐酸美贝维林（MBHCl）的含量。
将磷酸钨酸添加到盐酸美贝维林中，并与聚合物基质（聚氯乙烯，PVC）和增塑剂-硝基苯辛基醚混合，制备了美贝维林-磷钨酸盐（MB-PT）。新提出的传感器在 1.0×10-1.0×10 mol L 的选定分析物的线性检测范围内表现出优异的线性，回归方程为 E =（-29.429±0.2）log[MB]+347.86。然而，未功能化的传感器 MB-PT 在 1.0×101.0×10 mol L 药物溶液中的线性较差，回归方程为 E =（-26.603±0.5）log[MB]+256.81。考虑到许多因素，按照分析方法学要求的规则，改进了建议的电位测定系统的适用性和有效性。
所创建的电位测定技术可很好地用于测定原料药和市售药物样品中的 MB。
