Al-Mohaimeed Amal M, Mostafa Gamal A E, El-Tohamy Maha F
Department of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11451, Saudi Arabia.
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Polymers (Basel). 2021 Dec 20;13(24):4459. doi: 10.3390/polym13244459.
Electrically conductive polymeric nanocomposites with nanoparticles are adaptable types of nanomaterials that are prospective for various applications. The extraordinary features of copper oxide (CuO) and aluminium oxide (AlO) nanostructures, encourages extensive studies to prospect these metal oxide nanocomposites as potential electroactive materials in sensing and biosensing applications. This study suggested a new CuO/AlO nanocomposite-based polymeric coated wire membrane sensor for estimating naltrexone hydrochloride (NTX) in commercial formulations. Naltrexone hydrochloride and sodium tetraphenylborate (Na-TPB) were incorporated in the presence of polymeric polyvinyl chloride (PVC) and solvent mediator -nitrophenyloctyl ether (-NPOE) to form naltrexone tetraphenylborate (NTX-TPB) as an electroactive material. The modified sensor using NTX-TPB-CuO/AlO nanocomposite displayed high selectivity and sensitivity for the discrimination and quantification of NTX with a linearity range 1.0 × 10-1.0 × 10 mol L and a regression equation E = (58.25 ± 0.3) log [NTX] + 754.25. Contrarily, the unmodified coated wire sensor of NTX-TPB exhibited a Nernstian response at 1.0 × 10-1.0 × 10 mol L and a regression equation E = (52.1 ± 0.2) log [NTX] + 406.6. The suggested modified potentiometric system was validated with respect to various criteria using the methodology recommended guidelines.
含纳米颗粒的导电聚合物纳米复合材料是一类适应性强的纳米材料，在各种应用中具有广阔前景。氧化铜（CuO）和氧化铝（AlO）纳米结构的非凡特性，促使人们广泛开展研究，以期将这些金属氧化物纳米复合材料作为传感和生物传感应用中的潜在电活性材料。本研究提出了一种基于CuO/AlO纳米复合材料的新型聚合物包覆丝膜传感器，用于测定市售制剂中的盐酸纳曲酮（NTX）。在聚合聚氯乙烯（PVC）和溶剂介质硝基苯基辛基醚（-NPOE）存在的情况下，将盐酸纳曲酮和四苯基硼酸钠（Na-TPB）结合，形成四苯基硼酸纳曲酮（NTX-TPB）作为电活性材料。使用NTX-TPB-CuO/AlO纳米复合材料的修饰传感器对NTX的鉴别和定量显示出高选择性和灵敏度，线性范围为1.0×10 - 1.0×10 mol/L，回归方程为E = (58.25 ± 0.3) log [NTX] + 754.25。相反，NTX-TPB的未修饰包覆丝传感器在1.0×10 - 1.0×10 mol/L时表现出能斯特响应，回归方程为E = (52.1 ± 0.2) log [NTX] + 406.6。使用推荐指南中的方法，对所建议的修饰电位系统的各项标准进行了验证。
