Al Omar Suliman Y, Al-Mohaimeed Amal M, El-Tohamy Maha F
Doping Research Chair, Zoology Department, College of Science, King Saud University, Riyadh University, Riyadh-11451, Kingdom of Saudi Arabia.
Department of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia.
Heliyon. 2023 Apr 26;9(5):e15793. doi: 10.1016/j.heliyon.2023.e15793. eCollection 2023 May.
The extraordinary features of cerium oxide (CeO) and zinc oxide (ZnO) nanostructures have encouraged substantial attention to those nanocomposites as probable electroactive complexes for sensing and biosensing purposes. In this study, an advanced novel factionalized CeO/ZnO nanocomposite-aluminum wire membrane sensor was designed to assess pethidine hydrochloride (PTD) in commercial injection samples. Pethidine-reineckate (PTD-RK) was formed by mixing pethidine hydrochloride and ammonium reineckate (ARK) in the presence of polymeric matrix (polyvinyl chloride) and -nitrophenyl octyl ether as a fluidizing agent. The functionalized nanocomposite sensor displayed a fast dynamic response and wide linearity for the detection of PTD. It also revealed excellent selectivity and sensitivity, high accuracy, and precision for the determination and quantification of PTD when compared with the unmodified sensor PTD-RK. The guidelines of analytical methodology requirements were obeyed to improve the suitability and validity of the suggested potentiometric system according to several criteria. The developed potentiometric system was suitable for the determination of PTD in bulk powder and commercial products.
氧化铈（CeO）和氧化锌（ZnO）纳米结构的非凡特性促使人们对这些纳米复合材料作为用于传感和生物传感目的的潜在电活性复合物给予了大量关注。在本研究中，设计了一种先进的新型分段CeO/ZnO纳米复合铝线膜传感器，用于评估商业注射样品中的盐酸哌替啶（PTD）。盐酸哌替啶与雷氏铵盐（ARK）在聚合物基质（聚氯乙烯）和作为流化剂的邻硝基苯基辛基醚存在下混合形成哌替啶雷氏盐（PTD-RK）。功能化纳米复合传感器在检测PTD时表现出快速的动态响应和宽线性范围。与未修饰的传感器PTD-RK相比，它在PTD的测定和定量方面还显示出优异的选择性和灵敏度、高精度和精密度。根据若干标准遵守分析方法要求的指导方针，以提高所建议的电位系统的适用性和有效性。所开发的电位系统适用于散装粉末和商业产品中PTD的测定。
