Shawky Ahmed Mahmoud, El-Tohamy Maha Farouk
Science and Technology Unit (STU), Umm Al-Qura University, Makkah 21955, Saudi Arabia.
Department of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia.
Polymers (Basel). 2021 Apr 23;13(9):1384. doi: 10.3390/polym13091384.
The advanced and high-functional activities of magnesium oxide and copper oxide nanoparticles encourage the extensive use of these metal oxides as remarkable electroactive materials in electrochemical and sensing detections. The current study described a comparative sensing activity and selectivity of modified coated wire membrane sensors enriched with magnesium oxide and copper oxide nanoparticles for quantifying the breast cancer medication letrozole (LTZ) in its pharmaceutical form and human plasma. The fabricated sensors were based on the incorporation of LTZ with phosphomolybdic acid (PMA) to form the electroactive complex letrozole-phosphomolybate (LTZ-PM) in the presence of -nitrophenyloctyl ether (-NPOE) as a solvent mediator. Under optimum conditions, the modified sensors LTZ-PM-MgONPs and LTZ-PM-CuONPs demonstrated linear relationships of 1.0 × 10-1.0 × 10 and 1.0 × 10-1.0 × 10 mol L, respectively. Least square equations were calculated as E = (56.4 ± 0.7) log [LTZ] + 569.6 and E = (58.7 ± 0.3) log [LTZ] + 692.6 for LTZ-PM-MgONPs and LTZ-PM-CuONPs, respectively. The conventional type LTZ-PM showed a potential response E = (53.3 ± 0.5) log [LTZ] + 451.4 over concentration range of 1.0 × 10-1.0 × 10 mol L. The suggested sensors were successfully used to determine LTZ in pharmaceutical formulations and biosamples. Method validation ensured the suitability of the suggested potentiometric sensors.
氧化镁和氧化铜纳米颗粒的先进且高效的功能特性促使这些金属氧化物作为卓越的电活性材料在电化学和传感检测中得到广泛应用。当前的研究描述了富含氧化镁和氧化铜纳米颗粒的修饰涂丝膜传感器在定量测定其药物形式和人血浆中的乳腺癌药物来曲唑（LTZ）时的比较传感活性和选择性。所制备的传感器基于在作为溶剂介质的对硝基苯基辛基醚（-NPOE）存在下，将LTZ与磷钼酸（PMA）结合形成电活性络合物来曲唑 - 磷钼酸盐（LTZ - PM）。在最佳条件下，修饰后的传感器LTZ - PM - MgONPs和LTZ - PM - CuONPs分别在1.0×10⁻¹.0×10⁻⁶和1.0×10⁻¹.0×10⁻⁷mol/L范围内呈现线性关系。对于LTZ - PM - MgONPs和LTZ - PM - CuONPs，最小二乘方程分别计算为E = (56.4 ± 0.7) log [LTZ] + 569.6和E = (58.7 ± 0.3) log [LTZ] + 692.6。传统类型的LTZ - PM在1.0×10⁻¹.0×10⁻⁶mol/L浓度范围内显示出电位响应E = (53.3 ± 0.5) log [LTZ] + 451.4。所建议的传感器成功用于测定药物制剂和生物样品中的LTZ。方法验证确保了所建议的电位传感器的适用性。
