Romańczyk Marcin, Budzyń Krzysztof, Romańczyk Tomasz, Lesińska Magdalena, Koziej Mateusz, Hartleb Marek, Waluga Marek
Endoterapia, H-T. Centrum Medyczne, Aleja Bielska 105, 43-100, Tychy, Poland.
Chair and Department of Gastroenterology and Hepatology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
Dysphagia. 2023 Apr;38(2):629-640. doi: 10.1007/s00455-022-10492-8. Epub 2022 Jul 9.
Cervical inlet patches (CIP) are common endoscopic findings with uncertain pathogenesis and clinical significance. We aimed to perform a systematic review and prospective study of clinical data and endoscopic findings related to CIP. It was a prospective single-center study conducted between 10/01/2017 and 9/01/2018. Forty patients with histopathologically confirmed CIP were compared with 222 individuals in the reference group. The systematic review was executed in accordance with the PRISMA guideline. Alcohol consumption tended to be higher among patients with CIP (3.0 ± 4.6 vs. 1.9 ± 5.0 standard drinks/week CIP patients and reference group, respectively; p < 0.001). Dysphagia was more frequent among patients with CIP (25% vs. 1.4%, CIP patients and reference group, respectively; p < 0.001), and sore throat and hoarseness were less frequent in patients with CIP (17.5% vs. 26.6% CIP patients and reference group, respectively; p < 0.01). In the multivariate regression analysis, the only risk factor of CIP occurrence was dysphagia (OR 21.9, 95%CI 4.9-98.6; p < 0.001). Sore throat and hoarseness were a reverse-risk factor of CIP diagnosis (OR 0.3, 95%CI 0.1-0.93; p = 0.04). Clinical data and coexisting endoscopic findings were not related to CIP. In the presented study, dysphagia was related to CIP occurrence, and sore throat and hoarseness tended to be less frequent among patients with CIP.
宫颈入口斑块（CIP）是常见的内镜检查结果，其发病机制和临床意义尚不明确。我们旨在对与CIP相关的临床数据和内镜检查结果进行系统评价和前瞻性研究。这是一项于2017年1月10日至2018年1月9日进行的前瞻性单中心研究。将40例经组织病理学确诊的CIP患者与222例参照组个体进行比较。系统评价按照PRISMA指南执行。CIP患者的酒精摄入量往往更高（分别为3.0±4.6与1.9±5.0标准饮酒量/周，CIP患者组与参照组；p<0.001）。CIP患者中吞咽困难更为常见（分别为25%与1.4%，CIP患者组与参照组；p<0.001），而CIP患者中咽痛和声音嘶哑则较少见（分别为17.5%与26.6%，CIP患者组与参照组；p<0.01）。在多因素回归分析中，CIP发生的唯一危险因素是吞咽困难（比值比21.9，95%置信区间4.9 - 98.6；p<0.001）。咽痛和声音嘶哑是CIP诊断的反向危险因素（比值比0.3，95%置信区间0.1 - 0.93；p = 0.04）。临床数据和并存的内镜检查结果与CIP无关。在本研究中，吞咽困难与CIP的发生有关，且CIP患者中咽痛和声音嘶哑往往较少见。
