Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, USA. Electronic address: https://twitter.com/@madkinsthreats.
Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, USA; Department of Pathology & Immunology, Baylor College of Medicine, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, USA.
Curr Opin Genet Dev. 2022 Aug;75:101948. doi: 10.1016/j.gde.2022.101948. Epub 2022 Jul 6.
Recent studies using cell lineage-tracing techniques, organoids, and single-cell RNA sequencing analyses have revealed: 1) adult organs use cell plasticity programs to recruit progenitor cells to regenerate tissues after injury, and 2) plasticity is far more common than previously thought, even in homeostasis. Here, we focus on the complex interplay of normal stem cell differentiation and plasticity in homeostasis and after injury, using the gastric epithelium as a touchstone. We also examine common features of regenerative programs and discuss the evolutionarily conserved, stepwise process of paligenosis which reprograms mature cells into progenitors that can repair damaged tissue. Finally, we discuss how conserved plasticity programs may help us better understand pathological processes like metaplasia.
最近使用细胞谱系追踪技术、类器官和单细胞 RNA 测序分析的研究揭示：1）成年器官利用细胞可塑性程序在损伤后招募祖细胞来再生组织，2）可塑性比以前认为的要普遍得多，即使在体内平衡中也是如此。在这里，我们关注的是胃上皮作为试金石的体内平衡和损伤后正常干细胞分化和可塑性的复杂相互作用。我们还研究了再生程序的共同特征，并讨论了后生作用的进化保守、逐步过程，该过程将成熟细胞重新编程为可以修复受损组织的祖细胞。最后，我们讨论了保守的可塑性程序如何帮助我们更好地理解化生等病理过程。
