Wei Jing, Zhao Mantong, Meng Keke, Xia Guanghua, Pan Yonggui, Li Congfa, Zhang Weimin
Hainan Engineering Research Center of Aquatic Resources Efficient Utilization in South China Sea, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Key Laboratory of Seafood Processing of Haikou, College of Food Science and Engineering, Hainan University, Haikou, China.
Key Laboratory of Tropical Fruits and Vegetables Quality and Safety for State Market Regulation, Hainan Institute for Food Control, Haikou, China.
Front Nutr. 2022 Jun 23;9:930506. doi: 10.3389/fnut.2022.930506. eCollection 2022.
The acute and prolonged diuretic effects of coconut water (CW) and the underlying mechanism were investigated with a saline-loaded rat model. In an acute diuretic experiment, CW could significantly increase urine excretion. In addition, the treatment of CW significantly increased urinary sodium and chloride ions, thereby considerably increasing the excretion of NaCl. However, the calcium concentration and pH value were not affected. In the prolonged diuretic experiment, CW dramatically increased the urine output and urine electrolyte concentrations (Na, K, and Cl). Furthermore, CW could suppress the activation of renin-angiotensin-aldosterone system by decreasing serum antidiuretic hormone, angiotensin II, and aldosterone levels, and significantly increasing the serum atriopeptin level. CW treatment significantly reduced the mRNA expressions and protein levels of aquaporin 1 (AQP1), AQP2, and AQP 3. This report provided basic data for explaining the natural tropical beverage of CW as an alternative diuretic agent.
利用盐水负荷大鼠模型研究了椰子水（CW）的急性和长期利尿作用及其潜在机制。在急性利尿实验中，CW可显著增加尿量。此外，CW处理显著增加尿钠和氯离子，从而显著增加NaCl的排泄。然而，钙浓度和pH值不受影响。在长期利尿实验中，CW显著增加尿量和尿电解质浓度（钠、钾和氯）。此外，CW可通过降低血清抗利尿激素、血管紧张素II和醛固酮水平，并显著增加血清心房肽水平来抑制肾素-血管紧张素-醛固酮系统的激活。CW处理显著降低水通道蛋白1（AQP1）、AQP2和AQP 3的mRNA表达和蛋白水平。本报告为解释天然热带饮料CW作为替代利尿剂提供了基础数据。
