Jing Yanyan, Zhao Jie, Yang Zhen, Yao Senbang, Tang Lingxue, Li Wen, Yu Sheng, Cheng Huaidong
Department of Oncology, The Second Affiliated Hospital of Anhui Medical University Hefei 230601, Anhui, China.
Department of Oncology, Anhui Medical University Hefei 230032, Anhui, China.
Am J Cancer Res. 2022 Jun 15;12(6):2721-2732. eCollection 2022.
This study aimed to evaluate the effectiveness and feasibility of CALM (managing cancer and living meaningfully), which is a psychotherapeutic intervention used to reduce cancer-related fatigue (CRF) and improve quality of life (QOL) in Chinese gastrointestinal cancer survivors (GCs). A total of 115 GCs were enrolled in this study. All patients were randomly assigned to either the CALM group or the usual care (UC) group. All patients were evaluated using the Piper Fatigue Scale (PFS) and Quality of Life Assessment Scale before and after 2, 4, and 6 CALM or UC sessions with GCs presenting with severe fatigue. We compared the differences in these scores between the CALM group and the UC group and analyzed the correlations between CRF and QOL scores. Compared with the UC group, the CALM group showed significant differences in total CRF, behavioral/daily life CRF, emotional/affective CRF, sensory/physical CRF, cognitive CRF and QOL scores before and after 2, 4, and 6 CALM sessions (F=3106.434, F=1113.831, F=1159.919, F=1502.266, F=820.275, F=606.513, respectively; P<0.001). Finally, negative correlations were found between CRF and QOL scores in the GCs in the CALM group (before treatment: r=-0.46, P=0.0002; after 2 sessions: r=-0.46, P=0.0002; after 4 sessions: r=-0.51, P<0.0001; after 6 sessions: r =-0.44, P=0.0004). The CALM intervention effectively reduced fatigue in cancer patients and improved their QOL. This study suggests that CALM as a psychotherapeutic intervention may be an effective way to reduce CRF.
本研究旨在评估CALM（有意义地管理癌症）的有效性和可行性，CALM是一种心理治疗干预措施，用于减轻中国胃肠道癌症幸存者（GCs）的癌症相关疲劳（CRF）并改善生活质量（QOL）。本研究共纳入115名GCs患者。所有患者被随机分为CALM组或常规护理（UC）组。所有患者在接受2次、4次和6次CALM或UC治疗前后，使用派珀疲劳量表（PFS）和生活质量评估量表进行评估，这些治疗针对有严重疲劳症状的GCs患者。我们比较了CALM组和UC组这些评分的差异，并分析了CRF与QOL评分之间的相关性。与UC组相比，CALM组在接受2次、4次和6次CALM治疗前后，总CRF、行为/日常生活CRF、情绪/情感CRF、感觉/身体CRF、认知CRF和QOL评分存在显著差异（F值分别为3106.434、1113.831、1159.919、1502.266、820.275、606.513；P<0.001）。最后，在CALM组的GCs患者中发现CRF与QOL评分之间存在负相关（治疗前：r=-0.46，P=0.0002；2次治疗后：r=-0.46，P=0.0002；4次治疗后：r=-0.51，P<0.0001；6次治疗后：r=-0.44，P=0.0004）。CALM干预有效地减轻了癌症患者的疲劳并改善了他们的生活质量。本研究表明，CALM作为一种心理治疗干预措施可能是减轻CRF的有效方法。
