Hickey D R, O'Connor J P, Donati F
Can J Anaesth. 1987 May;34(3 ( Pt 1)):280-3. doi: 10.1007/BF03015165.
Succinylcholine 2-5 mg or atracurium 10-15 mg were given on five separate occasions to a 24-year-old, 64 kg woman homozygous for atypical plasma cholinesterase who was undergoing electroconvulsive therapy (ECT). Atracurium blockade was reversed with atropine, 0.6 mg and edrophonium, 35 mg. Train-of-four stimulation was applied to the ulnar nerve and the force of contraction of the adductor pollicis muscle was recorded. Doses producing 90 per cent first twitch blockade were 2.5 and 15 mg for succinylcholine and atracurium respectively. The onset of action was 6 min for both relaxants, and time to 90 per cent first twitch recovery was 20 min for succinylcholine and 16 min for the atracurium-edrophonium combination. It is concluded that the use of atracurium in these patients does not offer marked advantages over small doses of succinylcholine.
在5个不同时间，分别给予一名24岁、体重64kg、纯合子非典型血浆胆碱酯酶的女性琥珀酰胆碱2 - 5mg或阿曲库铵10 - 15mg，该女性正在接受电休克治疗（ECT）。用0.6mg阿托品和35mg依酚氯铵逆转阿曲库铵的阻滞作用。对尺神经施加四个成串刺激，并记录拇内收肌的收缩力。产生90%首次颤搐阻滞的剂量，琥珀酰胆碱为2.5mg，阿曲库铵为15mg。两种松弛剂的起效时间均为6分钟，琥珀酰胆碱至90%首次颤搐恢复的时间为20分钟，阿曲库铵 - 依酚氯铵组合为16分钟。结论是，在这些患者中使用阿曲库铵相对于小剂量琥珀酰胆碱并无明显优势。
