Zhao Fen, Sun Xiaoning, Wang Yingyan, Zhou Yunqing, He Yingzhong, Wang Cuijin, Han Feng, Liu Jie, Tsai Shao-Yu, Wang Guanghai, Wang Jiwen
Department of Pediatric Neurology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Paediatric Translational Medicine Institute, Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Nat Sci Sleep. 2022 Jul 2;14:1225-1236. doi: 10.2147/NSS.S367900. eCollection 2022.
To investigate the association between sleep disturbances and behavioral problems as well as quality of life (QOL) in Chinese children with epilepsy.
Caregivers of 167 epileptic children aged 3 to 12 years completed the Child Sleep Habits Questionnaire (CSHQ), the Strengths and Difficulties Questionnaire (SDQ), and the Pediatric Quality of Life Inventory (PedsQL™, 4.0 Core).
The prevalence of sleep disturbances (CSHQ total score >41) in epileptic children was 73.7% [95% CI (66.9%.80.4%)]. Epileptic children with sleep disturbances demonstrated more behavioral problems and lower QOL compared to those without sleep disturbances. Sleep disturbances such as sleep anxiety and daytime sleepiness were associated with more behavioral problems and lower QOL ( <0.05). Linear regression analyses showed that higher disturbance in sleep duration domain were associated with more behavioral problems, while higher sleep disordered breathing domains was associated with lower QOL ( <0.05). The interaction between sleep disturbances and behavioral problems in predicting QOL was not significant. The sensitivity analysis using 48 as an alternative cutoff for CSHQ total score obtained consistent results.
Sleep disturbances occur frequently among Chinese children with epilepsy, and are associated with more behavioral problems and lower QOL. The sleep disturbance-QOL association is unlikely contingent on behavioral problems. This study highlights the necessity of evaluating and treating sleep disturbances multidimensionally among children with epilepsy to promote their whole health and wellbeing.
探讨中国癫痫患儿睡眠障碍与行为问题以及生活质量（QOL）之间的关联。
167名3至12岁癫痫患儿的照料者完成了儿童睡眠习惯问卷（CSHQ）、长处与困难问卷（SDQ）以及儿童生活质量量表（PedsQL™，4.0核心版）。
癫痫患儿睡眠障碍（CSHQ总分>41）的患病率为73.7%[95%置信区间（66.9%，80.4%）]。与无睡眠障碍的癫痫患儿相比，有睡眠障碍的癫痫患儿表现出更多行为问题且生活质量更低。睡眠焦虑和日间嗜睡等睡眠障碍与更多行为问题及更低生活质量相关（P<0.05）。线性回归分析表明，睡眠时间领域的更高障碍与更多行为问题相关，而睡眠呼吸障碍领域的更高障碍与更低生活质量相关（P<0.05）。睡眠障碍与行为问题在预测生活质量方面的交互作用不显著。使用48作为CSHQ总分的替代临界值进行的敏感性分析得出了一致的结果。
中国癫痫患儿中睡眠障碍频繁发生，且与更多行为问题及更低生活质量相关。睡眠障碍与生活质量的关联不太可能取决于行为问题。本研究强调了对癫痫患儿的睡眠障碍进行多维度评估和治疗以促进其整体健康和幸福的必要性。
