Wang Hayson Chenyu, Li Yunzhu, Li Zhujun, Wang Liquan, Li Ziming, Long Xiao
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Plastic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Front Med (Lausanne). 2022 Jun 23;9:945691. doi: 10.3389/fmed.2022.945691. eCollection 2022.
Microcirculation plays a vital role in scleroderma physiopathology and the mechanism of fat survival.
This study aims to assess the blood perfusion change after fat grafting and evaluate the relationship between blood perfusion and fat graft retention in patients with localized scleroderma (LS).
A pilot study was conducted in patients with LS receiving autologous fat grafting (AFG). Fat graft retention measured by magnetic resonance imaging (MRI) analysis and blood flow perfusion measured by laser speckle contrast imaging 6 months postoperatively were noted. PUMC Localized Scleroderma Facial Aesthetic Index was used to assess the improvement of facial aesthetic impairment.
The fat retention at the 6-month follow-up was 34.56 ± 11.89 percent. At the 6th month of follow-up, the relative blood perfusion at the lesion area was 115.08 ± 14.39 PU, significantly higher than 100.42 ± 10.62 PU at the pre-operation ( = 0.010). The blood perfusion at follow-up increased by an average of 1.15 ± 0.14 times before the operation. No association between the increase in the blood flow perfusions and fat graft retention was found ( = -0.082, = 0.811).
Local blood perfusion in the lesion area relatively increased after AFG, but no direct relationship was found between fat retention and increased blood supply.
微循环在硬皮病生理病理学及脂肪存活机制中起着至关重要的作用。
本研究旨在评估脂肪移植后局部硬皮病（LS）患者的血液灌注变化，并评价血液灌注与脂肪移植留存率之间的关系。
对接受自体脂肪移植（AFG）的LS患者进行一项初步研究。记录术后6个月通过磁共振成像（MRI）分析测量的脂肪移植留存率以及通过激光散斑对比成像测量的血流灌注情况。采用中国医学科学院北京协和医院局部硬皮病面部美学指数评估面部美学损伤的改善情况。
6个月随访时脂肪留存率为34.56±11.89%。随访第6个月时，病变区域的相对血液灌注为115.08±14.39灌注单位（PU），显著高于术前的100.42±10.62 PU（P = 0.010）。随访时的血液灌注较术前平均增加了1.15±0.14倍。未发现血流灌注增加与脂肪移植留存率之间存在关联（P = -0.082，r = 0.811）。
AFG后病变区域的局部血液灌注相对增加，但未发现脂肪留存与血液供应增加之间存在直接关系。
