Han Shunxin, Liu Juzi, Lu Feng, Cai Junrong
Department of Plastic and Reconstructive Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Front Surg. 2024 Aug 23;11:1457593. doi: 10.3389/fsurg.2024.1457593. eCollection 2024.
The application of autologous fat transplantation in facial lesions of patients with localized scleroderma (LoS) has been reported in recent years.
The authors report a case of worsening of active localized scleroderma after autologous fat transplantation.
A man presented with neck and facial skin atrophy and pigmentation with a history of LoS. Appearing 1.5 years ago, the lesion had progressively grown in size and shape. Consent was obtained after the patient was informed of the possible surgical risks during the active phase of the disease. He underwent autologous fat grafting into the right cheek with about 30 ml Coleman fat graft.
Skin dyspigmentation and atrophy progressively deteriorated 1 month into therapy, with slightly increased erythema and enlargement of the lesion. Six months after the therapy, the localized scleroderma-related score worsened.
There are different factors, such as that systemic medications could affect the treatment of localized scleroderma by autologous fat transplantation. Meanwhile, considering the limitation of the 6-month follow-up period, obtaining long-term follow-up data is necessary to evaluate sustained outcomes and potential complications.
More clinical research is needed to determine the time interval between disease inactivity and the application of any surgical procedures to avoid reactivation.
近年来已有自体脂肪移植应用于局限性硬皮病（LoS）患者面部病变的报道。
作者报告1例自体脂肪移植后活动性局限性硬皮病病情恶化的病例。
1例男性患者，有LoS病史，表现为颈部和面部皮肤萎缩及色素沉着。病变于1.5年前出现，大小和形状逐渐增大。在患者被告知疾病活动期可能的手术风险后获得了同意。他接受了约30 ml科尔曼脂肪移植至右侧脸颊。
治疗1个月后皮肤色素沉着和萎缩逐渐恶化，红斑略有增加，病变扩大。治疗6个月后，局限性硬皮病相关评分恶化。
存在不同因素，如全身用药可能影响自体脂肪移植治疗局限性硬皮病。同时，考虑到6个月随访期的局限性，有必要获得长期随访数据以评估持续疗效和潜在并发症。
需要更多的临床研究来确定疾病静止期与任何手术操作应用之间的时间间隔，以避免病情复发。
