Dou Shu-Hui, Cui Yu, Huang Shu-Ming, Zhang Bo
Department of Neuroscience, Institute of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.
Department of Veterinary Medicine, College of Agriculture, Hainan University, Haikou, China.
Front Hum Neurosci. 2022 Jun 24;16:924155. doi: 10.3389/fnhum.2022.924155. eCollection 2022.
Recent studies have found abnormal levels of brain-derived neurotrophic factor (BDNF) in a variety of central nervous system (CNS) diseases (e.g., stroke, depression, anxiety, Alzheimer's disease, and Parkinson's disease). This suggests that BDNF may be involved in the pathogenesis of these diseases. Moreover, regulating BDNF signaling may represent a potential treatment for such diseases. With reference to recent research papers in related fields, this article reviews the production and regulation of BDNF in CNS and the role of BDNF signaling disorders in these diseases. A brief introduction of the clinical application status of BDNF is also provided.
最近的研究发现，在多种中枢神经系统（CNS）疾病（如中风、抑郁症、焦虑症、阿尔茨海默病和帕金森病）中，脑源性神经营养因子（BDNF）水平异常。这表明BDNF可能参与了这些疾病的发病机制。此外，调节BDNF信号传导可能是治疗这些疾病的潜在方法。本文参考相关领域的最新研究论文，综述了CNS中BDNF的产生和调节以及BDNF信号传导紊乱在这些疾病中的作用。还简要介绍了BDNF的临床应用现状。
