菊苣酸：天然存在、化学合成、生物合成及其生物活性作用

Yang Min, Wu Chao, Zhang Tianxi, Shi Lei, Li Jian, Liang Hongbao, Lv Xuzhen, Jing Fengtang, Qin Lu, Zhao Tianlun, Wang Chenxi, Liu Guangxu, Feng Shuai, Li Feng

Teaching and Research Office of Chinese Medicines authentication, College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.

Department of Pharmaceutical Preparation Technology, Department of Pharmaceutical Engineering, Shandong Drug and Food Vocational College, Weihai, China.

Front Chem. 2022 Jun 23;10:888673. doi: 10.3389/fchem.2022.888673. eCollection 2022.

Chicoric acid has been widely used in food, medicine, animal husbandry, and other commercial products because of its significant pharmacological activities. However, the shortage of chicoric acid limits its further development and utilization. Currently, (L.) Moench serves as the primary natural resource of chicoric acid, while other sources of it are poorly known. Extracting chicoric acid from plants is the most common approach. Meanwhile, chicoric acid levels vary in different plants as well as in the same plant from different areas and different medicinal parts, and different extraction methods. We comprehensively reviewed the information regarding the sources of chicoric acid from plant extracts, its chemical synthesis, biosynthesis, and bioactive effects.

由于其显著的药理活性，菊苣酸已广泛应用于食品、医药、畜牧业和其他商业产品中。然而，菊苣酸的短缺限制了其进一步的开发和利用。目前，菊苣是菊苣酸的主要天然来源，而其他来源鲜为人知。从植物中提取菊苣酸是最常见的方法。同时，不同植物以及同一植物的不同产地、不同药用部位和不同提取方法的菊苣酸含量也有所不同。我们全面综述了有关从植物提取物中获取菊苣酸的来源、其化学合成、生物合成及生物活性作用的信息。