Centre Hospitalier de l'Université de Montréal (CHUM) et Centre de Recherche du CHUM (CRCHUM), Université de Montréal, QC, Canada; Département de Psychiatrie et d'Addictologie, Faculté de Médecine, Université de Montréal, QC, Canada.
Centre Hospitalier de l'Université de Montréal (CHUM) et Centre de Recherche du CHUM (CRCHUM), Université de Montréal, QC, Canada.
Psychiatry Res. 2022 Sep;315:114709. doi: 10.1016/j.psychres.2022.114709. Epub 2022 Jul 3.
Intermittent theta burst stimulation (iTBS) using 600 pulses is an effective and FDA-cleared transcranial magnetic stimulation (TMS) protocol for major depressive disorder (MDD). Prolonged iTBS (piTBS) using 1,800 pulses could increase the effectiveness of TMS for MDD, but its real-world effectiveness is still debated. We assessed the safety, tolerability, and preliminary effectiveness of a 3x daily piTBS 1,800 pulses protocol delivered over 2 weeks in 27 participants. Only four participants (18.2%) achieved response, two of them achieving remission (9.1%). Five participants (18.5%) experienced tolerability issues. Future studies should focus on the neurophysiological effects of TBS protocols to determine optimal parameters.
采用 600 脉冲的间歇性 theta 爆发刺激（iTBS）是一种有效且获得 FDA 批准的用于治疗重度抑郁症（MDD）的经颅磁刺激（TMS）方案。采用 1800 脉冲的延长 iTBS（piTBS）可以提高 TMS 治疗 MDD 的效果，但其实用效果仍存在争议。我们评估了为期 2 周内每天 3 次给予 27 名参与者 1800 脉冲 piTBS 的安全性、耐受性和初步疗效。只有 4 名参与者（18.2%）达到了缓解标准，其中 2 名达到了完全缓解（9.1%）。有 5 名参与者（18.5%）出现了耐受性问题。未来的研究应侧重于 TBS 方案的神经生理学效应，以确定最佳参数。
Eur Arch Psychiatry Clin Neurosci. 2023-10
Zotero 插件