两种本地河豚鱼在因哈卡岛的麻痹性贝类毒素和类似物 - 莫桑比克南部：莫桑比克海岸的首次报告。

Tetrodotoxin and analogues in two local pufferfish species from Inhaca Island - South of Mozambique: First report in the Mozambican coast.

机构信息

CIIMAR/CIMAR-LA-Interdisciplinary Center of Marine and Environmental Research, University of Porto, Terminal de Cruzeiros do Porto de Lexiões, Avenida General Norton de Matos, 4450-238, Matosinhos, Portugal; Institute of Biomedical Science Abel Salazar, University of Porto, R. Jorge de Viterbo Ferreira 228, 4050-313, Porto, Portugal; Department of Chemistry, Faculty of Sciences, Eduardo Mondlane University, Av. Julius Nyerere, n 3453, Campus Principal, Maputo, 257, Mozambique.

Marine Biology Station of Inhaca, Faculty of Sciences, Eduardo Mondlane University, Av. Julius Nyerere, nr 3453, Campus Principal, 257, Maputo, Mozambique.

出版信息

Toxicon. 2022 Sep;216:88-91. doi: 10.1016/j.toxicon.2022.06.011. Epub 2022 Jul 9.

DOI:10.1016/j.toxicon.2022.06.011

PMID:35817092

Abstract

Tetrodotoxins (TTXs) were investigated in two local pufferfish species, Diodon hystrix and Arothron hispidus, from Mozambican coast. TTX and analogues 4-epiTTX, 4,9-anhydroTTX, 11-deoxyTTX, and 11-norTTX-6-(R/S)-ol were found in both species and high level of TTX was found in A. hispidus (9522.0 μg TTX kg) than in D. hystrix (350.9 μg TTX kg). The distribution of TTX and their analogues in A. hispidus was intestine > liver > skin ≫ muscle > gonads. This is the first report of TTXs in Mozambican coast.

摘要

在来自莫桑比克沿海的两种本地河豚鱼，Diodon hystrix 和 Arothron hispidus 中研究了河豚毒素 (TTXs)。在这两种鱼中都发现了 TTX 和类似物 4-表 TTX、4,9-脱水 TTX、11-去氧 TTX 和 11-去甲 TTX-6-(R/S)-醇，并且在 A. hispidus 中发现了高水平的 TTX（9522.0μg TTX kg），而在 D. hystrix 中则发现了较低水平的 TTX（350.9μg TTX kg）。TTX 及其类似物在 A. hispidus 中的分布为肠道>肝脏>皮肤>肌肉>性腺。这是莫桑比克沿海地区首次报告 TTXs 的存在。