Institución Universitaria Visión de las Américas, Pereira, Colombia; Fundación Universitaria Autónoma de las Américas, Pereira, Colombia; Instituto para la Investigación en Ciencias Biomédicas - Sci-Help, Pereira, Colombia.
Instituto para la Investigación en Ciencias Biomédicas - Sci-Help, Pereira, Colombia; Universidad Tecnológica de Pereira, Pereira, Colombia.
Int J Infect Dis. 2022 Sep;122:832-840. doi: 10.1016/j.ijid.2022.07.017. Epub 2022 Jul 9.
Aedes-borne viruses (ABV) affect humans on every inhabited continent and frequently cause epidemics. Recent epidemics of chikungunya and Zika viruses (ZIKV) highlight that preparedness for future epidemics requires assessment of susceptibility, particularly among high-risk groups. We sought to determine immunity against the three major circulating ABV among pregnant women in an ABV-endemic area of Colombia.
A cross-sectional seroprevalence study was performed, enrolling women presenting to Labor and Delivery. Cord blood and maternal peripheral blood samples were obtained. IgG seroprevalence to flaviviruses and chikungunya was determined by ELISA. An abbreviated neutralization test was used to estimate the frequency and magnitude of immunity to Zika and four dengue serotypes. Cluster analyses explored epidemiologic factors associated with seroprevalence.
Most women exhibited high levels of neutralizing antibodies to one or more ABV; however, nearly 20% were seronegative for flaviviruses. Our research took place after the epidemic peak of the ZIKV outbreak in Colombia in 2016. However, only 20% of pregnant women had high levels of Zika-neutralizing antibodies consistent with likely protective immunity to ZIKV.
Hence, a high proportion of pregnant women in Risaralda remain susceptible to one or more ABV including the teratogenic ZIKV, indicating a risk for future epidemics in this region.
蚊媒病毒（ABV）影响着每个有人居住的大洲的人类，并且经常引发流行病。最近的基孔肯雅热和寨卡病毒（ZIKV）流行凸显出，为未来的流行病做好准备需要评估易感性，尤其是在高风险人群中。我们试图确定哥伦比亚 ABV 流行地区孕妇对三种主要循环 ABV 的免疫力。
进行了一项横断面血清流行率研究，招募了在分娩时就诊的妇女。采集脐血和产妇外周血样本。通过 ELISA 测定黄病毒和基孔肯雅热的 IgG 血清阳性率。使用简化的中和试验来估计对 Zika 和四种登革热血清型的免疫频率和幅度。聚类分析探讨了与血清流行率相关的流行病学因素。
大多数女性对一种或多种 ABV 表现出高水平的中和抗体；然而，近 20%的人对黄病毒呈血清阴性。我们的研究是在 2016 年哥伦比亚 ZIKV 爆发的流行高峰期之后进行的。然而，只有 20%的孕妇具有高水平的 Zika 中和抗体，这与对 ZIKV 可能具有保护作用的免疫相一致。
因此，里萨拉尔达的很大一部分孕妇仍然容易受到一种或多种 ABV 的感染，包括致畸性的 ZIKV，这表明该地区未来存在流行病的风险。
