Aux/IAA 蛋白降解动力学的内在和外在调节因子。
Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics.
机构信息
Department of Biology, Duke University, Durham, NC, USA.
Department of Biology, Duke University, Durham, NC, USA.
出版信息
Trends Biochem Sci. 2022 Oct;47(10):865-874. doi: 10.1016/j.tibs.2022.06.004. Epub 2022 Jul 8.
Abstract
The plant hormone auxin acts through regulated degradation of Auxin/INDOLE-3-ACETIC ACID (Aux/IAA) proteins to regulate transcriptional events. In this review, we examine the composition and function of each Aux/IAA structural motif. We then focus on recent characterization of Aux/IAA N-terminal disordered regions, formation of secondary structure within these disordered regions, and post-translational modifications (PTMs) that affect Aux/IAA function and stability. We propose how structural variations between Aux/IAA family members may be tuned for differential transcriptional repression and degradation dynamics.
摘要
植物激素生长素通过调节Auxin/INDOLE-3-ACETIC ACID（Aux/IAA）蛋白的降解来调节转录事件。在这篇综述中，我们研究了每个 Aux/IAA 结构基序的组成和功能。然后，我们重点研究了最近对 Aux/IAA N 端无规则区域的特征描述、这些无规则区域内二级结构的形成以及影响 Aux/IAA 功能和稳定性的翻译后修饰（PTMs）。我们提出了 Aux/IAA 家族成员之间的结构变化如何被微调以实现差异转录抑制和降解动力学。
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